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What are the factors influencing oral sustained- release dosage form design?
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∙ 14y ago
Factors influencing oral sustained-release dosage form design include drug properties (such as solubility, stability, and half-life), desired release profile, site of absorption in the gastrointestinal tract, manufacturing feasibility, patient compliance, and regulatory requirements. Additionally, considerations such as cost-effectiveness, formulation complexity, and technology advancement may also impact the design of sustained-release dosage forms.
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What are some biological factors which influence oral sustained-release dosage form design?
They include:Biological half-lifeCompounds with a half-life which is shorter than 8 hours and shorter than 2 hours are good for sustained release formulations. On the other hand, drugs with a short half life yet long duration of action are not suitable for sustained release formulations.AbsorptionThe rate of release should be slower than the rate of absorption. In other words, the overall absorption rate of the drug should be consistent with the rate of release of the drug from the dosage form. Drugs which have a poor absorption are not suitable for sustained released formulations.MetabolismMetabolism can occur in the intestine. When compared with a bolus dose, sustained release increases the chances of the drugs being metabolised as they are released one by one.Margin of safety and therapeutic effectsDrugs with a narrow therapeutic window are dangerous candidates as failure of choosing the correct dosage form may lead to accidental overdose.
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