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Bioavailability is the amount of drug which reaches the site of physiological activity after administration.
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There are many factors that can influence it but I don't know.
How quickly a drug clears from the body is a function of its absorption, bioavailability, distribution, metabolism, and excretion properties.
Bioavailability measures the amount of a drug (medicinal) or other substance which enters the blood. This depends on two types of factors: 1) The physical and chemical properties of the drug. If a drug is insoluble (ie does not dissolve) in the stomach or intestine it is unlikely to be absorbed into the blood, so its bioavailability will be low. If it is soluble it is more likely to be absorbed so its bioavailability will be high. 2) The route in which it is given. Direct injection into the blood gives 100% bioavailability. Taking a drug by mouth is likely to give less than 100% bioavailability. For more details see: http://www.merck.com/mmpe/sec20/ch303/ch303c.html
relationship between the first pass effect and bioavailability
Bioavailability of a drug is the amount of the drug that is available for use by the body after it has been metabolised by the liver.
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