What is the bioavailability of a drug?
Bioavailability of a drug is the amount of the drug that is available for use by the body after it has been metabolised by the liver.
Bioavailability is the amount of drug which reaches the site of physiological activity after administration. Read More
biovability of intral nasal route Read More
yes Read More
How does chemical stability of the drugs in the gastrointestinal tact affect the bio-availability of the drugs?
Bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, so we need chemically stable drug in order to increase the chance of drug absorbance and thus increased bioavailability. Read More
Bioavailability measures the amount of a drug (medicinal) or other substance which enters the blood. This depends on two types of factors: 1) The physical and chemical properties of the drug. If a drug is insoluble (ie does not dissolve) in the stomach or intestine it is unlikely to be absorbed into the blood, so its bioavailability will be low. If it is soluble it is more likely to be absorbed so its bioavailability will… Read More
It is not recommended that you consume grapefruit products while taking this drug. Grapefruit increases the bioavailability of the drug, which increases the changes of drug toxicity. Read More
They can still have different bioavailability (the amount of drug that is delivered to the site of action and the rate at whcih it is available). Pharmacetical equivalents do not have to have the same release mechanisms, and can therefore affect their bioavailability. Read More
Pharamceutical agents which used in formulation to enhance the absorptuion of drug (through gastro intestinal tract) and hence its concentration in blood are called bioavailability enhancers. Some of the exaples are Cremophor, Gattefossse, Labrafil, Labrasol etc. Read More
How quickly a drug clears from the body is a function of its absorption, bioavailability, distribution, metabolism, and excretion properties. Read More
Many factors can contribute to affect the bioavailability of the orally administered drugs. Briefly, these includes gastric emptying rate, intestinal transit time, hepatic first pass metabolism, and gastrointestinal and hepatic blood flow etc. apart from these factors, disease conditions, diet and dosage form also contribute in alteration of the bioavailability of the drugs. Read More
What effect does crushing Dexedrine sr spanules have on potency efficiency and bioavailability of the active drug?
Enteric-coated drugs (time released/ sustained release capsules) don't disintegrate in the stomach b/c they are protected by the stomach acid. This drug has to reach an alkaline (non-acidic) environment (which is the small intestine) in order to disintegrate and get into the blood stream. Enteric coated tablets can remain in the stomach for a long time b/c they are protected from the acidic environment. Crushing dexedrine SR (beaded) capsules would alter the place and time… Read More
IM means Intramuscular route of drug administration, while IV means Intraveinal route of drug administration. IV route, takes the drug directly into the bloodstream resulting in 100% bioavailability instantly. Where as in IM route, drug is injected into muscle tissues, which holds the drug for a while and gradually releases into the bloodstream through the network bed of capillaries running across or surrounding the muscle tissue. In IM, the bioavailability may be slightly less than… Read More
The stability of a drug is the ability of the drug to maintain its chemical, physical, therapeutic and toxicological properties throughout its shelf life. Often times environmental and other unexplainable factors affect the stability of drugs by causing degradation of either the active ingredient of the drug product or the excipients, reducing the bioavailability of the drug or changing the physical appearance of the drug. Read More
Bioavailability refers to the amount of a vitamin that is absorbed and used by the body. When a folate supplement is taken on an empty stomach, the bioavailability is 100 percent. Read More
J. B. Dressman has written: 'Oral drug absorption' -- subject(s): Pharmaceutical Preparations, Biological Availability, Solubility, Oral Administration, Bioavailability, Metabolism, Oral medication Read More
cardiovascular drugs Read More
CASCAVAL Read More
Ethanol is a form of alcohol. Bioavailability is the extent and rate of a subtance's entry into the body's circulation system, so bioavailability of ethanol refers to the extent and rate of ethanol's entry into the body's circulation system. Ethanol in the gastric contents slows the peristaltic action that moves food through the stomach and delays stomach emptying. Read More
Intravenous (IV) Read More
77% Intranasal 90% by mouth Read More
Basically no, due to two reasons: First, the drug is incompletely absorbed from the gastrointestinal tract, some of it exits the body unabsorbed along with the feces. Second, the absorbed amount of the drug undergoes first-pass metabolism; where the drug enters the hepatic portal system and is partly metabolized by the liver, thus, the amounts of drug reaching the systemic circulation unchanged is even less. Therefore, the bioavailability of orally administered drugs is always below… Read More
The amount absorbed and subsequently used by the body. Read More
raw egg whites Read More
Broccoli is highest. I am assuming its kale. Read More
The amount of vitamins from your diet, without considering the vitamin supplements Read More
Nicola A. Barrett has written: 'Bioavailability of benorylate in hot beverages' Read More
Yes. Much better, in fact. Buprenorphine has a much higher bioavailability sublingually than orally. You also have to consider the bioavailability of naloxone, which is almost nil sublingually. I don't know how much higher it is orally, but ideally, you want none of it. Read More
You can but you should be aware that sodium diclofenac can reduce the bioavailability and hence the effectiveness of amoxicillin Read More
not really... giving a drug IV just ensures that all of it gets into your system. when you swallow something the absorption can be variable and usually isn't 100%, especially when you're sick. IV drugs have good "bioavailability." the "potency," as the term is used by pharmacists and doctors, doesn't change. Read More
Yes it can. They even make morphine suppositories. The bioavailability is a bit higher that way. Read More
What is the most nutrient dense source of calcium because of its high bioavailability and low calorie content?
non-fat milk Read More
The effect will increase with anything alkaline, such as baking soda or calcium pills. The easiest way is just to take Tums or Rolaids; it tastes better and will increase the bioavailability of amphetamine in your system. Also, avoid taking adderall with anything acidic like fruit juices, especially citrus, as these increase the acidity in your stomach and reduce the effect of the drug. Read More
Yes. Keep in mind that the bioavailability is higher, so you need to use less rectally than you would eat. the bioavailability is about: 40-60% orally 60-70% insufflated (snorted) 70-90% rectally Read More
Ziprasidone (if it's taken with food, either before or after, will increase its bioavailability) Read More
Avoids first pass effect in the liver and there is high bioavailability of the drug in the body. "Some medications are best administered into the subcutaneous tissue by a needle. This route has the advantage of almost complete absorption, providing the patient's circulation is good; therefore an accurate measure of the amount of the drug absorption is possible. Medicines administered in this manner are not affected by gastric disturbances (although it should be remembered that… Read More
Which plant is preffered the most for mixed cropping in order to enhance the bioavailability of nitrogen?
Legumenous plant like Cajanus cajan (pegeon pea) Read More
In layman's terms, bio-availability applies to "how much of this drug, when administered orally, is actually absorbed?" I.e how much of the drug is "available" for the body to utilize? What makes it a more confusing concept is that bio-availablity of the same drug, at the same dosage, is not the same for every person. (Although you can at least hope they are similar, which enables drugs to have standardized dosages). One of the primary… Read More
What will happen to the drug after first pass elimination when taken orallyWill the concentration of the drug decrease?
Depending on the drug, first pass can have a major influence on it's fraction reaching systemic circulation. F = fa x fg x fh Essentially the fraction reaching the systemic circulation or bioavailability (F) is influenced by fa - absorption from intestine, fg = fraction escaping metabolism in the gut, and fh = fraction escaping the first pass (metabolism) by the liver carried via the portal vein. The amount of drug reaching the systemic circulation… Read More
Quite simply, yes. However, the bioavailability is very low, meaning that it is terribly inefficient way to deliver LSD to the brain. Read More
Gholamhossein Kabir has written: 'In vivo and in vitro assessment of vitamin B6 bioavailability in humans' -- subject(s): Vitamin B6 Read More
From their point of view, injectable morphine has a much greater bioavailability, (less is needed), is effective immediately, and they feel they have the skills to administer it properly. Read More
Is there any possibility that a generic version of Adderall is not exactly the same as Adderall if it says generic for Adderall on the label?
Generics are supposed to be "bioequivalent" to the brand name drugs, meaning that they use the same active ingredients and work with the same speed of action. The FDA does allow a 20% variance in bioavailability (i.e., the fraction of an administered dose of unchanged drug that reaches the systemic circulation) compared to the bio-availability of the brand name drug. In addition, the color and shape of the tablet and the binders that hold it… Read More
This is what Chlorpromazine is for. Antipsychosi(Bi-Polar etc.) Chlorpromazine is chemically brokedown into a Benzodiazapine Pharmacokinetics Chlorpromazine, and many other phenothiazine derivatives, are very lipophilic molecules that readily bind with membranes and proteins. Approximately 95-98% of the drug is bound in the plasma; 85% of the drug is bound to the plasma protein albumin. Renal disease may cause this range to expand significantly. Highest concentrations of the drug can be found in the brain, lung… Read More
If you mix alcohol and marijuana into a solution and place it on your skin will it enter into your blood stream?
Yes, but in very small amounts. The epidermal bioavailability of Δ9-THC is very low. Read More
This is done to reduce the drug's toxicity and increase its bioavailability. It still needs to be high enough to meet its absorption criteria though. Read More
It depends on how many ml's you have. I'm assuming you have a liquid solution? Say your bottle has 10 ml left in it. Well then you have 200 mg. That's quite a bit. Now you have to consider mode of getting it in your body. Is it syrup? Is it injectable? I believe doing IV gives you best bioavailability , but lasts least amount of time. Sub Q shot is next, then Im and… Read More