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Can a drug which is 100 percent absorbed from GI tract have 100 percent bioavailability?
Wiki User
∙ 12y ago
yes
Wiki User
∙ 12y ago
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What is the bioavailability of a drug?
Bioavailability of a drug is the amount of the drug that is available for use by the body after it has been metabolised by the liver.
How route of administration drug can control bioavailability drug?
biovability of intral nasal route
How does chemical stability of the drugs in the gastrointestinal tact affect the bio-availability of the drugs?
Bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, so we need chemically stable drug in order to increase the chance of drug absorbance and thus increased bioavailability.
How many grams of a drug must be used to prepare 5000 milliliters of a 1 percent solution?
You need 50 g of this drug.
1g of a drug is dissolved in 2.5mL of solution what is the percentage strength of the solution ww How do you calculate percent ww when 1g of drug is dissolved in 2.5mL of solution?
40%
Bio availabilty has a better feature when it gets dissolved or undissolved?
Bioavailability measures the amount of a drug (medicinal) or other substance which enters the blood. This depends on two types of factors: 1) The physical and chemical properties of the drug. If a drug is insoluble (ie does not dissolve) in the stomach or intestine it is unlikely to be absorbed into the blood, so its bioavailability will be low. If it is soluble it is more likely to be absorbed so its bioavailability will be high. 2) The route in which it is given. Direct injection into the blood gives 100% bioavailability. Taking a drug by mouth is likely to give less than 100% bioavailability. For more details see: http://www.merck.com/mmpe/sec20/ch303/ch303c.html
What is the bioavailability of a drug?
Bioavailability of a drug is the amount of the drug that is available for use by the body after it has been metabolised by the liver.
What is bioavailability?
Bioavailability is the amount of drug which reaches the site of physiological activity after administration.
What are bioavailability enhancers?
Bioavailability enhancers are substances that can increase the absorption and availability of a drug or nutrient in the body. They work by improving the solubility of the compound, protecting it from degradation in the gastrointestinal tract, or enhancing its permeability across cell membranes, ultimately leading to higher levels of the compound reaching the systemic circulation.
What is a bioequivalence?
A bioequivalent is a formulation of a drug which is equivalent to some other formulation in terms of bioavailability.
What is bioavilability in pharmacology?
Bioavailability in pharmacology refers to the fraction of a drug that reaches the systemic circulation and is available to produce an effect after administration. It is typically expressed as a percentage and takes into account how much of the administered dose is absorbed and becomes available to the body. Factors like drug formulation, route of administration, and first-pass metabolism can affect a drug's bioavailability.
How route of administration drug can control bioavailability drug?
biovability of intral nasal route
Can bioavailability be more than 100 percent for orally administred drugs?
Basically no, due to two reasons:First, the drug is incompletely absorbed from the gastrointestinal tract, some of it exits the body unabsorbed along with the feces.Second, the absorbed amount of the drug undergoes first-pass metabolism; where the drug enters the hepatic portal system and is partly metabolized by the liver, thus, the amounts of drug reaching the systemic circulation unchanged is even less.Therefore, the bioavailability of orally administered drugs is always below a 100% and can never be a 100%.Moreover, its not logical for it to be more than 100%, since bioavailability by definition is the fraction of the amount of the drug administered that reaches the systemic circulation unchanged. It can't be more than 100% unless larger amounts of the drug reaches your circulation than the amount you already took orally, which is impossible.While it cannot be more than 100% for a single dose, if the drug is administered more often than the period necessary for complete elimination from the body, total serum concentration may be higher than 100% of the single dose. Such is the case with most antibiotics for example, which are administered at intervals of 4-6-12 hours to achieve and maintain plasma concentrations higher than the single dose. (PS I am not a health professional)
How does chemical stability of the drugs in the gastrointestinal tact affect the bio-availability of the drugs?
Bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, so we need chemically stable drug in order to increase the chance of drug absorbance and thus increased bioavailability.
What effect does crushing Dexedrine sr spanules have on potency efficiency and bioavailability of the active drug?
Enteric-coated drugs (time released/ sustained release capsules) don't disintegrate in the stomach b/c they are protected by the stomach acid. This drug has to reach an alkaline (non-acidic) environment (which is the small intestine) in order to disintegrate and get into the blood stream. Enteric coated tablets can remain in the stomach for a long time b/c they are protected from the acidic environment. Crushing dexedrine SR (beaded) capsules would alter the place and time of absorption of the drug so it wouldn't be able to provide the correct therapeutic effects. The rapid absorption of the drug would increase the bioavailability of the drug and would cause an increase in drug concentration. Drug toxicity could result. With the SR tablet it is slowly absorbed and limits the bioavailability of the drug, decreasing the drug serum concentration. -nursing student/ ADD patient and Dexedrine prescribed for 15 yrs.
What is the medical term meaning extent to which a drug or other substance becomes available to the body?
Bioavailability
What is bioenhancer?
A bioenhancer is a biological enhancer - any naturally-occurring compound which increases drug bioavailability.
