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A bioequivalent is a formulation of a drug which is equivalent to some other formulation in terms of bioavailability.
Wiki User
ā 8y ago
Wiki User
ā 8y agoA bioequivalency is another term for a bioequivalence, a measure of the equivalence of multiple formulations of a drug in terms of bioavailability.
Wiki User
ā 8y agoA bioequivalence is a measure of the equivalence of multiple formulations of a drug in terms of bioavailability.
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What does bioequivalence in pharmaceuticals mean?
bioequivalence study is must to cheak the quality of such a pharmaceutical
What is negative formulary list?
It is a list of trade-name drugs that pharmacies may not dispense generic drugs in lieu of. The drug that the physician writes on the prescription must be dispensed by the pharmacist. Pharmaceutical companies claim there exist small differences in bioavailability and bioequivalence in generic drugs that could affect patient outcomes in those with critical illnesses or conditions.
What does bio analytical in pharmaceutical industry mean?
i have not came across such terminology yet. it may mean: 1. a bioavailability study/method/process 2. a bioequivalence study/method/process 3. analysis of concentration of a drug in blood, tissue, etc. 4. analytical instruments used for such study. 5. study of absorption, distribution, metabolism and excretion profile on animals or humans.
Is generic medicines approved by a regulatory authority?
Even for equivalent medicines the marketing authorization is provided by the regulatory authorities like FDA. However, manufacturers of generics do not have to repeat the safety and efficacy studies: these in fact had already been conducted by the originator of the product manufacturer at the time of the first approval. Simply so that present to the Agency a dossier demonstrating the bioequivalence of the product, the ability of the production and the measures adopted to ensure the quality control process.
Is oxycodone stronger than endocet?
It depends on the strength. First, the active pain-killing narcotic ingredient in this medication is oxycodone. Percocet is made by a company called Endo. They also make a generic version called Endocet. With the exception of the pill's imprint and sometimes the color, both Percocet and Endocet are identical - from the oxycodone to the APAP to the fillers to the binders to the coatings. So, if you're asking if a 10/325 Endocet is stronger than a 10/325 Percocet, the answer is no - they are completely identical. The Endocet brand is the only generic made by the company that makes Percocet, and is no different than taking brand-name Percocet. The other generic brands (the most common being Tyco-Mallinckrodt, Watson, and Interpharm) are not made by Percocet and instead adhere to the FDA's regulations on bioequivalence, using differing binders, fillers, and coatings. The amount of the active drug, oxycodone, is always regulated and identical.
Double dummy in blind clinical trials?
Double-Dummy A technique for retaining the blind when administering supplies in a clinical trial, when the two treatments cannot be made identical. Supplies are prepared for Treatment A (active and indistinguishable placebo) and for Treatment B (active and indistinguishable placebo). Subjects then take two sets of treatment; either A (active) and B (placebo), or A (placebo) and B (active). Difficulties in achieving the double-blind ideal can arise: the treatments may be of a completely different nature, for example, surgery and drug therapy; two drugs may have different formulations and, although they could be made indistinguishable by the use of capsules, changing the formulation might also change the pharmacokinetic and/or pharmacodynamic properties and hence require that bioequivalence of the formulations be established; the daily pattern of administration of two treatments may differ. One way of achieving double-blind conditions under these circumstances is to use a 'double-dummy' technique. This technique may sometimes force an administration scheme that is sufficiently unusual to influence adversely the motivation and compliance of the subjects. Ethical difficulties may also interfere with its use when, for example, it entails dummy operative procedures. Nevertheless, extensive efforts should be made to overcome these difficulties.
what is adderall pill?
What are the best Adderall Dosages for ADHD? For All Patients Dosage is set according to the therapeutic needs and responsibility of the patient. Adderall XR is advisable at the lowest effective dosage. On the basis of the Bioequivalence data, it has been concluded that patients can switch to ADDERALL XR once daily from what they were receiving in the form of multiple divided doses throughout the day ( for example, BD/TID). However, in order to achieve adequate and appropriate efficacy coupled with tolerability, the doses can be titrated under the HCPs' supervision on a weekly basis. ADDERALL XR available in the form of Capsules that you can take either wholly or they can simply take by opening the capsules and sprinkling them on applesauce. However, there is some advice that needs to be religiously followed when opting for the sprinkling method. This includes immediate consumption of the sprinkled applesauce; it is easy to store. The Sprinkled beads from the capsule must be ingested as a whole and must not be chewed. To ensure you receive the complete dose and don't miss the efficacy chart, the dose of a single capsule must not be divided. One capsule per day is advisable to consume and not less than to maintain the drug concentration in the body of the patient. As discussed with the above example of applesauce, ADDERALL XR is easy to take with or without food. ADDERALL XR has the potential to cause Insomnia if taken in the afternoon. Thus, to avoid unnecessary late-night sleeplessness, it is advisable to take it in the morning. Children Children aging 6-12 years who are suffering from ADHD and for whom the HCP has made a decision to initiate their treatment with ADDERALL. And for those children who are moving from another medication, can start with 10mg OD in the morning; the dose is easy to titrate with Ā±5 or 10 mg at weekly intervals. Under the HCPās guidance, a lower starting dose of 5mg OD in the morning can also be opted for. The maximum recommended dose of ADDERALL in children is 30 mg/day; doses higher than 30 mg/day of ADDERALL XR have not yet been studied in children. Also, ADDERALL XR has not been studied in children under six years of age. So, there is no written guidance for its use in children below six. However, its use depends on the experience of the doctor. Adolescents The recommended dose for starting the therapy in adolescents with ADHD who are 13-17 years of age and are either initiating treatment first time or are moving from another medication is 10 mg/day. The dose is easy to increase to 20 mg/day after one week if you do not achieve adequate control. Adults For adults with ADHD, the recommended dose is 20 mg/day whether they are starting treatment for the first time or switching from another medication. Conclusion Dosage is set according to the therapeutic needs and responsibility of the patient. Adderall XR is advisable at the lowest effective dosage. Buy ADDERALL XR available in the form of Capsules that you can take either wholly or they can simply take by opening the capsules and sprinkling them on applesauce. However, there is some advice that needs to be religiously followed when opting for the sprinkling method.
Is dog diazepam the same they give to a human?
Diazepam (Common trade name of Valium) is a member of the Benzodiazepine family. Diazepam has many uses in both animal and human conditions, however it is often used as an anxiolytic, and has been used sucessfully for a number of years in both animals and humans. It can also be given to epileptic pets in suppository form if suffering from status epilepticus. As with any medication there are some potential side effects which must be discussed with your vet. In some rare cases, it may have a paradoxical effect in which it cause excitement and exacerbates anxiety. Diazepam should only be given to animals under veterinary advice. There are other products and formulations for pets that suffer from anxiety disorders that may be more suitable depending on severity of condition, size of the animal and other factors. Other formulations such as syrups, elixirs, and drops are commonly available in which your veterinarian can advise upon if suitable. There are also many natural alternatives that you may consider discussing with your veterinarian. If your pet goes for surgery and it has been given any kind of calming substance, even the most natural one, you must tell the veterinarian so the given anesthesia is adjusted (decreased) so the total anesthesia is within the therapeutic window, as calming subtances contribute to this total.
What are the factors affecting bioavailability of orally administered drug?
Many factors can contribute to affect the bioavailability of the orally administered drugs. Briefly, these includes gastric emptying rate, intestinal transit time, hepatic first pass metabolism, and gastrointestinal and hepatic blood flow etc. apart from these factors, disease conditions, diet and dosage form also contribute in alteration of the bioavailability of the drugs.
What dose of Allegra can dogs take safely?
YES they can Cornell University did a study and it is safe and effective in many cases Yes. My vet prescribed it for our miniature Schnauzer I WOULD NOT give it to them unless you have gone to vet and asked if it was necessary or if there was a safe alternative
