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What are triptans?

Updated: 11/15/2022
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Celticfife

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12y ago

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The triptans are a class of medication used to abort migraine headaches. They can also be used on cluster headaches.

They work by plugging into the serotonin receptors in the brain, so that more serotonin is used - which then constricts the blood vessels of the body. This is important, because it is the dilated blood vessels in part that cause so much throbbing pain. Unlike pain medications, triptans don't cover up a migraine - they stop the whole process - including nausea and light sensitivity. The sooner you take it, the better it works.

There are seven different kinds of triptan. Each one works and binds in a slightly different way. Therefore, it is important to give all seven a chance. While several of them might not work for you, one might.

  • Imitrex [tablet, nasal spray, injection]
  • Maxalt [tablet, sublingual dissolving pill]
  • Zomig [tablet, sublingual, nasal spray]
  • Relpax [tablet]
  • Amerge [tablet]
  • Axert [tablet]
  • Frova [tablet]

    (used for menstrual migraine cycles, because it lasts for 24 hours)

If you have hemiplegic or basilar migraines, or have Heart disease - then the triptans are not for you. For people with risk factors, they can cause heart attack and stroke.

As with any abortive medication, triptans can cause rebound headache. The gold standard is to not take any abortive medication more than two times a week. This is especially important with the triptans, because they will stop working over time. Headache specialists suggest that a migraineur might put off their triptans' demise by alternating between one or two different triptans, so you aren't consistently using the same one.

The FDA has approved the triptan Treximet. It is not a new triptan, simply Imitrex (sumatriptan) repackaged with some Aleve (naproxen) mixed in. Studies have shown that by adding a dose of an anti-inflammatory NSAID like naproxen to sumatriptan, you increase its effectiveness and longevity.

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Abortive medications include triptans, ergot alkaloids, NSAIDs, combination analgesics, and antiemetics.


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May cause tingling, numbness, sensations of heat or flushing, dizziness , drowsiness, or pain at the injection site.


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Relpax is an abortive medicine in a special class of drugs called Triptans which were originally developed for the treatment of Mograine headaches. There are over 300 different types of headache disorders and treatment is based on which type you have. See a headache specialist for diagnosis and appropriate treatment for your specific problem.


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Yes, but it's a pretty old drug that has mostly (but not entirely) been superseded by chemically related drugs called "triptans".Methergine hailed originally from the laboratories of the great Swiss pharmaceutical company, Sandoz. It is chemically related to lysergic acid diethylamide (LSD), which itself was a hypothetical anti-migraine agent.


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Sumatriptan (brand name Imitrex) is in a class of medications called triptans. It was the first medication of this type developed to treat migraine attacks. Sumatriptan is a selective serotonin 5-hydroxytrptamine 1 receptor (5-HT1) receptor agonist, that when used at the first sign of a migraine attack may help abort (stop) the migrainous process.


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Some people react badly to sumatriptan, just as some people react badly to Penicillin. Treating migraines is all about trial and error, unfortunately. There may be other triptans you can take which do not cause you to feel worse (Zomig, Maxalt, Axert, Amerge, Relpax, Frova) I would not recommend Treximet, because that is just sumatriptan with naproxen added.


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