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Most small non polar molecules can diffuse across the membrane. Water is polar but diffuses across the cell through aquaporins. There are also proteins that actively transport substances across the cell membrane such as ions (ex.The Na/K pump). It can get a little confusing. I tried to be as simple as possible. I don't know if this is what you were looking for.

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12y ago
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Q: What can diffuse directly across the plasma membrane of a eukaryote cell?
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