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P53 it is an anzyme that monitorize the DNA and protect them from demagis.It is founded that its defective in 60% of cancer cells
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∙ 12y ago
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Is there a gene related to colon or rectal cancer?
In patients with colon or rectal cancer, the p53 gene is mutated 70% of the time
What is the most common mutation to genes?
p53 gene..approximately 50% of human cancers involve this mutation.
What role does p53 have in controlling cell division?
Cell division is regulated by the p53 gene and relates to cancer because Cancer is caused by uncontrolled cell divison
A cell with a defective p53 gene is likely to?
A defective P53 gene is likely to cause poor regulation of cell cycles. P53 is a protein that suppresses tumor production and is implicated as a factor in cancer development. It prevents genome mutation and damage. 50% of human tumors have mutated or deleted P53 genes.
Why is cancer a genetic disorder?
because, usually it is a defect in a tumor suppressing gene such as p53.
If p53 is a tumor suppressor gene why can it not stop cancer?
It may be able to once more research and testing is done. It has been shown, however, that just supplementing or replacing the damaged P53 can not be effectively used yet to suppress tumors since that would cause premature aging.
What is P53 and what does it have to do with cancer?
The human gene known as p53 is a tumor suppressor gene and malfunctions of it have been implicated in many cancer types. Research is using it to study the biology of cancer, as well as to develop new drug targets to cure certain cancers.In 1993, p53 protein was named Molecule of the Year by Science magazine. It is a protein that is very important for the regulation of cell cycles in humans and other multi-cellular organisms. p53 is also known as TP53 and several other names including tumor protein (EC :2.7.1.37), the "guardian of the genome", and the "Guardian Angel Gene" (because it works to prevent mutation or damage to the genome).Most recent genetic research is also promising in the search for cancer causes and treatments. The research indicates there is a relationship between development of cancer and insufficiency of the p53 gene.More than 50% of the tumors in humans show a mutation of or deletion of this gene. It is believed that various things can cause the mutations or damage/deletion of p53, such as DNA damage from chemicals, UV ray damage, and there are some known viruses that can inhibit the function of p53, such as Simian Virus 40 (SV40) and Human Papillomavirus (HPV), an STD.These viruses and DNA damage can inactivate p53, rendering it ineffective for tumor suppression.See more in related questions and links.
Who identified the p53 gene?
The p53 gene was identified in 1979 by Arnold Levine, David Lane, and William Old. It wasn't until 1989 that the gene was found to be a tumor suppressor.
What is p53 called?
"The Guardian Angel Gene"
What is the P53 gene function?
p53 is a gene that codes for a protein (p53) that is an important tumor suppressor. Although the number of pathways and roles of p53 continue to expand it is, perhaps, most well known for slowing cell proliferation or inducing apoptosis if DNA damage or uncontrolled growth is detected.
What makes some genes responsible for an increased risk of certain cancers?
Some genes, when they mutate, are more likely to cause cancer than others. For example, tumor suppressor genes, such as p53 or Rb (retinoblastoma), when mutated, can cause cells to lose control of their cell cycle and divide abnormally.
What are point mutations?
Point mutations are a knock out of a single A.A. pair that shifts the whole code causing cancer or miss development of all the proteins behind it. Point mutations can be seen in K-Ras gene and the innactivation of the P53 to not stop the genetic mutation to arrect the cell cycle. The p53 is a tumor repressing gene.
