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What is a coagulation cascade in a partial thromboplastin time test?
A coagulation cascade is the sequence of biochemical activities, involving clotting factors, that stop bleeding by forming a clot.
Why does the coagulation cascade happen so fast?
Hemostasis
What factor 7?
Factor VII is one of the proteinsthat causes blood to clot in the coagulation cascade.
Formation of thromboplastin?
Thromboplastin, also known as tissue factor, is released from damaged tissues or activated platelets during blood vessel injury. It initiates the extrinsic pathway of the coagulation cascade by forming a complex with coagulation factor VII, triggering the cascade that ultimately leads to the formation of a blood clot.
What factor initiates the coagulation cascade in vivo?
In vivo, the coagulation cascade is initiated by tissue factor (TF) which is exposed to blood following vessel injury. TF forms a complex with factor VIIa, leading to activation of Factor X and subsequent activation of thrombin, resulting in fibrin formation and clot formation.
What coagulation factors are measured by the PT?
Prothrombin time (PT) measures the activity of coagulation factors in the tissue factor pathway of the coagulation cascade.
Why the blood does not clot in circulation despite having all the coagulation factors present?
Because coagulation requires a combination of platelet activation, activation of coagulation cascade (by trauma or damaged endothelial walls), and in predisposed individuals, abnormalities in regulator proteins such as protein C and anti-thrombin
What is the sequestering agent in anticoagulant sodium citrate solution?
Citrate chelates calcium, which is a necessary cofactor for several coagulation cascade enzymes.
How do coagulants work to promote blood clotting in the body?
Coagulants work by activating a series of proteins in the blood known as the coagulation cascade. This cascade leads to the formation of a blood clot, which helps to stop bleeding by sealing off the damaged blood vessel.
How is milk coagulated in the stomach?
It curdles in the stomach, which is the cause of coagulation.
What anticoagulant prevents coagulation of blood by removing calcium through the formation of insoluble calcium salt?
Sodium citrate is an anticoagulant that prevents coagulation of blood by removing calcium through the formation of insoluble calcium citrate salt. This process chelates calcium ions, preventing them from participating in the coagulation cascade.
What other words are associated with clotting?
Medical terms associated with clotting include thrombus, coagulation, and anticoagulant. The word "cascade" indicates the chain of chemical events involved with clotting.
