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There are many reasons...

-Migration into cities

-Poverty

-Water Supply

-Disease

-Famine

etc...

But it depends if you are talking about an LEDC (Less Economically Developed County) or MEDC (More Economically Developed Country). An LEDC would be some where in Africa for example and an MEDC would be the UK for example. It also depends on context. The answers I have given is geographical but you could be on about history or anything to be honest. Hope this helps.

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Q: What caused the widespread suffering in the cities?
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