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1. A cause of a lack of B12 can be mainly from three sources. The more common one is through not consuming enough. B12 is almost exclusively found (in enough amounts) in meat, shellfish, milk, and eggs. These foods tend to be off-limits to vegetarians and vegens, which can cause an insufficent amount of B12 being consumed in their diets. A less-likely reason is due to a parasite. Some parasites and worms live off of B12 and other essential vitamins to survive. An even less-likely reason is through a genetic abnormality where B12 is not able to be broken down and used by the body properly.

2. Nitrous oxide.

3. A B12 depletion and deficiency can also be caused by an auto immune condition affecting the stomach. This causes the destruction of the stomach lowering stomach acid or lowering production of intrinsic factor. Necessary to bond to b12 to be absorbed in the small intestines. Some prescription medicines may inhibit B12 absorption or lessen the amount you have in the body (antacids, laxatives, steroid meds, aspirin, diuretics, Birth Control pills, high doses of Vitamin C). Stomach or intestine surgeries can prevent proper b12 absorption as it may lower stomach acid, or intrinsic factor, or lessen absorption in the small intestines.

You can also develop a folic acid deficiency that can also be caused by certain meds such as (barbiturates, Tegretol, Depakote, Zarontin, Celontin, Primidone, Dilantin, Fosphenytoin, Ibuprofen, Anaprox, Motrin, Naprosyn, Naprelan, Pamprin, Voltaren). B12 and Folic Acid work hand in hand. Thus if you have a b12 depletion or deficiency you may also have a folic acid deficiency. If you supplement b12, it may be a good idea to also supplement with folic acid...Or make sure you b12 supplement contains also folic acid.

Other conditions that have been contributed to b12 deficiency are (Alcoholism, heavy metal levels such as mercury or lead, pregnancy).

People with aid/hiv, multiple sclerosis, Bells Palsy, Parkinson's, ALS, Muscular Distrophy, fibromyalgia, and some leukemias have reported b12 deficiencies.

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