Researchers at Texas Scottish Rite Hospital for Children (TSRHC), one of the nation's leading pediatric centers for research and the treatment of orthopaedic conditions, have identified the first gene -- CHD7 -- associated with idiopathic scoliosis (I.S.), the most common spinal deformity in children. With no known cause or cure, idiopathic scoliosis poses a significant health burden to the pediatric population. The condition affects approximately two to three percent of school age children in the U.S. and costs an estimated several billion dollars in surgical treatment each year. The medical breakthrough is a result of a 10-year study conducted at the Sarah M. and Charles E. Seay/Martha and Pat Beard Center for Excellence in Spine Research at Texas Scottish Rite Hospital for Children, led by Carol Wise, Ph.D. With the goal of identifying genes causing idiopathic scoliosis, the research team conducted genome-wide scans and follow-up studies of 53 large families, totaling 130 individuals with a confirmed I.S. diagnosis. As a result, the team identified the first gene associated with I.S., allowing the medical community to form hypotheses to explain what causes the condition, and providing tools for future studies. "This is the most definitive link between genetics and scoliosis that has been reported so far," said Dr. Wise, director of molecular genetics at Texas Scottish Rite Hospital for Children. "It has been known for many decades that scoliosis tends to be inherited within families, but now we have found a gene which is clearly related to the development of scoliosis." Most often seen in otherwise healthy children, I.S. is an S-shaped curvature of the spine as viewed from the front that develops as the child grows. Onset typically occurs during the period of rapid growth at adolescence, and children who are still growing, particularly girls, are at the greatest risk for developing severe disease. A long-known condition, I.S. was described by the ancient Greeks and affects all populations worldwide. "This discovery lays the groundwork for future research that will hopefully identify the specific abnormalities which cause the spine curvature," said Dr. Tony Herring, chief of staff at Texas Scottish Rite Hospital for Children. "When we understand these mechanisms, we may be able to develop new preventative measures and better treatment methods." With expert researchers, biomedical engineers, physicians, staff and patients all under the same roof, Texas Scottish Rite Hospital for Children has a record of interdepartmental cooperation that generates an exceptional number of patents, discoveries and improved treatments for patients. The hospital's prestigious research efforts and innovative treatment methods make it a leader in spine research and have allowed the hospital and its staff to significantly improve care of young patients with spinal deformities throughout Texas, the United States and the world. Texas Scottish Rite Hospital for Children is one of the nation's leading pediatric centers for the treatment of orthopedic conditions, certain related neurological disorders and learning disorders, such as dyslexia. There is no charge to patient families for treatment at the hospital, and admission is open to Texas children from birth to 18 years of age. This research was funded through generous contributions from: Fondation Yves Cotrel pour la Recherche en Pathologie Rachidienne de l'Institut de France and the Scoliosis Research Society. The hospital's work is also made possible through the establishment of the Pediatric Molecular Genetics Research Laboratory at Texas Scottish Rite Hospital for Children, which was funded by: The Crystal Charity Ball 1997; Beneke Companies; Horace C. Cabe Foundation; The Cain Foundation, in honor of Effie Marie Cain; The Florence Foundation; The Hillcrest Foundation, founded by Mrs. W. W. Caruth, Sr.; Hoblitzelle Foundation; The Hoglund Foundation; Kimberly Clark Corporation; Rauscher Pierce Refsnes; Mr. and Mrs. Jack Reynolds; The Harold Simmons Foundation; Mr. and Mrs. Douglas McWilliams Smith; The Roy and Christine Sturgis Charitable and Educational Trust; USLIFE Companies; and Mr. and Mrs.Terry Worrell.
Y chromosome
The precise chromosome is not known; future research may yield results.
Chromosome
Nail Patella Syndrome is found on chromosome #9. If you search "what chromosome is nail patella syndrome on?" in Google, then it will give you a bunch of websites that have a bunch of info. about it. hope this helps. :-)
Y i think
1. Scoliosis is NOT a DISEASE. It is a CONDITION. 2. Your question is grammatically incorrect. 3. It probably (don't quote me on this) has something to do with the second X chromosome. (Males have an X and a Y chromosome, and females have two X's)
Chromosome 7
Y chromosome
The gene associated with narcolepsy is found on chromosome 12 in humans. This gene is called HLA-DQB1*06:02 and is a key genetic factor contributing to susceptibility to narcolepsy.
They isolated three genes on chromosome 15 -- GABRA5, GABRB3 and GABRG3
The precise chromosome is not known; future research may yield results.
nucleus:)
GENETICS
26
X chromosome
Chromosome
It is a mutated gene called PKD1 located on chromosome 16.