I-40 and I-20 are essentially the same time.
I-40 - Jackson, TN is halfway (though you could stop in Memphis or Nashville if looking for larger cities)
I-20 - middle of nowhere AL is halfway...though Tuscaloosa, AL or Meridian, MS are the largest cities/towns around the halfway mark. If you're looking for a city then shoot for Jackson, MS or Birmingham, AL.
Kernersville
Greensboro, GA
The halfway point between Greensboro, NC and Charlotte, NC is Salisbury, NC
Pocomoke City, MD
If taking the Interstate 85 route, the approximate half-way point between Greensboro, NC and Phenix City, AL would be Anderson, South Carolina, at ~215 miles from each.
As the crow flies, the halfway point is just east-northeast of Uwharrie National Forest, south of Asheboro. Jamestown is about halfway from Charlotte to Raleigh, if you drive through Greensboro.
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Interstate 40, Cherokee National Forest, Hartford, TN 37753
Bracken, Indiana is halfway between Johnson City & Rhinelander
Cole, Maryland is halfway between Hagerstown & Ocean City
Halfway city between Atlanta and Charleston SC
what is the halfway point from miami to oklahoma city