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At the first checkpoint of the cell cycle, the cell has to ascertain whether it has all the nutrients and chemical compounds necessary for the next phase, which is Synthesis phase, which is predominated by DNA replication. Replication is a resource-intensive process and so the cell has to ensure it has sufficient building materials for the entire DNA to be replicated, that is, ribose sugar molecules, the nitrogen bases, sufficient ATP producing capability by it's mitochondria to allow the addition of each nucleotide. All this has to be accounted for before the cell can proceed with the process of replication.

Besides replication, it also has to ensure all other organelles are also in sufficient number or duplicated for the inevitable cytokinesis during mitosis.

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Q: What decision is made during the first checkpoint in the cell cycle?
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