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It is telling you how different the cells are from normal cells. Well differentiated is good, cells are similar to normal cells, moderately means cells are changing, and poorly differentiated means that cells have changed, it is a lower prognosis when it reaches this stage.

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16y ago
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13y ago

Absolutely! Moderately to poorly differentiated squamous cell carcinoma is treatable - these terms refer to the histologic grade of the tumor (how "bad" or "disorganized" it is). Well-differentiated SCC forms "keratin pearls" - or balls of skinn epithelium - within the tumor. Moderately to poorly differentiated tend not to do so, and instead are made of sheets of what can be "ugly"-looking cell.

The bottom line is that prognostically - in predicting a given patient's outcome - histological grade of SCC is not related very well at all to how well a patient will respond to treatment. The SIZE of the tumor and whether and lymph nodes are positive for metastasis of the tumor are much more predictive than the degree of differentiation.

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Q: What does moderately to poorly differentiated mean in the diagnosis of squamous cell carcinoma?
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From a previous answer from Answers.com:Absolutely! Moderately to poorly differentiated squamous cell carcinoma is treatable - these terms refer to the histologic grade of the tumor (how "bad" or "disorganized" it is). Well-differentiated SCC forms "keratin pearls" - or balls of skinn epithelium - within the tumor. Moderately to poorly differentiated tend not to do so, and instead are made of sheets of what can be "ugly"-looking cell.The bottom line is that prognostically - in predicting a given patient's outcome - histological grade of SCC is not related very well at all to how well a patient will respond to treatment. The SIZE of the tumor and whether and lymph nodes are positive for metastasis of the tumor are much more predictive than the degree of differentiation.Read more: http://wiki.answers.com/Is_moderate_to_poorly_differentiated_squamous_cell_carcinoma_treatable#ixzz1RTEm1slp


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