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Ciclosporin, cyclosporine or cyclosporin is an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system and, so, the risk of organ rejection. Initially isolated from a Norwegian soil sample, Ciclosporin A, the main form of the drug, is a cyclic nonribosomal peptide of 11 amino acids (an undecapeptide) produced by the fungus Beauveria nivea, and contains a single D-amino acid, which are rarely encountered in nature. Cyclosporine A is synthesized by a nonribosomal peptide synthetase, cyclosporine synthetase. The enzyme contains an adenylation domain, a thiolation domain, a condensation domain, and an N-methyltransferase domain. The adenylation domain is responsible for substrate recognition and activation, whereas the thiolation domain covalently binds the adenylated amino acids to phosphopantetheine and the condensation domain elongates the peptide chain. Generic ciclosporin preparations have been marketed under various trade names including Cicloral (Sandoz/Hexal) and Gengraf (Abbott).
Numbnuts just get straight to the damn answer the answer is Imperfect Fungi don't read all the useless crap
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∙ 13y ago
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∙ 14y agoimperfect fungi
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How are fungi related to cyclosporine?
Cyclosporine is a compound produced by some members of the fungal kingdom, most notably Tolypocladium niveum.
What is another name for Cyclosporine?
Sandimmune
Who discovered cyclosporine?
Jean-Francoise Borel in 1969
What type of drug is penicillin?
Penicillin is actually not a drug. The liquid that is produced by the Penicillin is also known as enzymes is used a as drug. Penicillin is used as antibiotics.
What is a drug that is produced by a chemical reaction in fruits vegetables and grains?
Alcohol
A soil fungus is one of the sources of cyclosporine this drug is given to patients who are about to receive an organ transplant cyclosporine suppresses the body's natural response to reject the organ?
Yes. Cyclosporin is an immunosuppressant medication. It is produced naturally by soil fungi
How are fungi related to cyclosporine?
Cyclosporine is a compound produced by some members of the fungal kingdom, most notably Tolypocladium niveum.
Side effects of general anesthesia cyclosporine predisonole?
Effects of Cyclosporine on Anesthetic Action Vincent N. Cirella, MD, Carol B. Pantuck, BA, Young Joo Lee, MD, PhD, and Eugene J. Pantuck, MD Received from the Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York. Abstract The effects of a single dose of cyclosporine on anesthetic actions of pentobarbital and fentanyl were studied in mice. Mice given pentobarbital 2 hr after receiving cyclosporine, 60 mg/kg, slept a statistically significant 2.3 times longer than did controls. In a second study, each of two dose levels of cyclosporine was given before each of four dose levels of fentanyl. The analgesic effect of fentanyl, measured with the abdominal constriction test, was dose-dependent. Cyclosporine significantly increased the analgesia produced by fentanyl and did so in a dose-dependent manner. Cyclosporine by itself did not produce analgesia. Plasma levels of fentanyl and binding of fentanyl by plasma proteins were unchanged by cyclosporine treatment. The results show that a single dose of cyclosporine can increase pentobarbital hypnosis and fentanyl analgesia in mice but do not establish the mechanism of these interactions. Key Words: IMMUNE RESPONSE, SUPPRESSION—cyclosporine • INTERACTIONS (DRUG)—cyclosporine, anesthetics
What are the dangers of stopping Cyclosporine without tapering it off?
If Cyclosporine users do not taper off the drug, some patients relapse and up with their organ transplantation becoming rejected. They also risk becoming extremely fatigued making it hard for them to even get around.
Who is the manufacturer of cyclosporine?
Can I get financial aide for the medicine Cyclosporine, my insurance does not cover it.
What drug has increased the successes of liver transplantations?
Since the introduction of cyclosporine (a drug that suppresses the immune response that rejects the donor organ), success rates for liver transplantation have reached 85%.
Can cyclosporine harm baby when pregnant?
Can cyclosporine harm the baby while 31 weeks pregnant?
What is the dosage for cyclosporine?
In general, cyclosporine is taken every 12 hours in liquid or capsule form.
Can you use alcohol while taking cyclosporine?
There is no reason not to consume alcohol with the immunosuppressant ciclosprin (also spelled cyclosporine & cyclosporin), in fact one brand name (neoral) of the drug contains a very small amount of absolute ethanol. Although it should be remembered that possible side effects of the drug can be impaired kidney and liver function which would be exacerbated by excessive consumption of alcohol.
Why is it necessary for doctors to give organ transplant patient a drug called cyclosporine?
After undergoing an organ transplant, it is necessary for patients to take drugs called immunosuppressants for the rest of their lives. Cyclosporine is a commonly used drug for this purpose. It is extremely important that people who have had a transplant take this drug every day as directed because if they don't, their body may reject the organ. The body's immune system recognizes the new organ as foreign and it attacks it. Drugs such as cyclosporine will suppress the immune system so that it cannot destroy the organ.
Briefe account on cyclosporine?
Cyclosporine suppresses T cells, which would otherwise tend to attack the tissues of a transplanted organ.
Does Grapefruit juice affect drug metabolism?
Grapefruit juice inhibits the metabolism of many medications, including cyclosporine, felodipine, nifedipine, nitrendipine, nisoldipine, carbamazepine, triazolam, and midazolam
