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Depends if the mum is O+ / O-, and if the first child is rh + or rh-. The fathers blood type is irrelevent except for that in this case in means that the unborn baby could be either rh+ or rh-.

If the mum is O- and the first baby was O+ then it is possible that the mum may have developed Anti D (an immune response to the 1st babys rh + antigen), if this is the case and this mum is now pregnant with another rh+ baby then she may mount an immune response to the baby causing Haemolytic disease of the newborn (HDN) or potentially miscarrying the baby. HDN usually just means a very anaemic baby.

During/ after the first pregnancy the mum should have been monitored and if it were needed given a dose of propholactic anti D, which would prevent her from making her own anti D, thus avoiding any risk to the second baby. During the second pregnancy any anti D made by the mum would be detected by the blood bank and steps taken to protect the unborn baby.

Just for clarity- if the blood group is O+ this means the group is O and the rh factor is present eg. rh+. O- means group O, rh- etc.

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Q: What effect can the rh factor have on a second child if the mothers blood type is o and the husband blood type is ab negative?
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