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Adderall usually raises cortisol levels. Most substances or experiences which trigger fight or flight type responses like stimulants will do this. ADHD and other illness that are treated by Adderall are thought to involve disruptions in the HPA axis. For most real ADHD sufferers this increase in cortisol is thought to cause improvement in symptoms and it is rare that someone without abnormal adrenal function experiences high cortisol (Cushing's) symptoms.

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Q: What effect does Adderall have on cortisol levels?
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