It is 169B to exit from I-26 onto I-95 nortbound toward Florence.
Take I-26 WEST from Charleston to I-95 NORTH to FLORENCE at EXIT 169B.Take I-95 NORTH to U.S. 378 to TURBEVILLE and SUMTER at EXIT 135.Turn left off the exit ramp onto U.S. 378 WEST to SUMTER; take U.S. 378 WEST to Sumter.
From Broad St in Charleston to the middle of Florence, SC. is a 136 mile trip if you take I-26W out of Charleston and connect with I-95N just up the road. It'll take 2hrs 4min depeinding on traffic or holiday conditions. However if you want less milage (113-123miles) and a slightly slower trip, try the 2.5 hour scenic trip. You can either take US 52W and then 52N or take SC 41N all the way and they will both get you safely into Florence.
191 milesTake I-26 WEST, from Charleston, to I-77 NORTH to CHARLOTTE at EXIT 116.Take I-77 NORTH to Fort Mill.
It is 213 miles taking this route:Take I-26 WEST, from Charleston, to I-385 NORTH to GREENVILLE at EXIT 51.Take I-385 NORTH to Greenville.
If you are talking about Charleston, SC, the route that you would take to I-95 is US-17 SOUTH to I-95 SOUTH. If you are talking about Charleston, WV, the route to I-95 is to take I-77 SOUTH through West Virginia, Virginia and North Carolina to where I-77 ENDS at I-26 in Columbia, SC. At I-26 take I-26 EAST TO I-95 to CHARLESTON. Then take I-26 EAST to I-95 SOUTH to SAVANNAH at EXIT 169A.From I-95 SOUTH:Take I-95 SOUTH though South Carolina and Georgia to I-295 SOUTH at EXIT 362B in Florida.Take I-295 around Jacksonville, FL to I-10 WEST to LAKE CITY at EXIT 21B.Take I-10 WEST to I-75 SOUTH to TAMPA at EXIT 296A near Lake City.Take I-75 SOUTH to I-275 SOUTH to TAMPA and ST. PETERSBURG at EXIT 274.Take I-275 SOUTH to Tampa.
60 miles taking this route:Take AZ LOOP 101 SOUTH to U.S. 60 (Superstition Fwy) EAST to GLOBE at EXIT 55A.Take U.S. 60 (Superstition Fwy) EAST to AZ-79 SOUTH to FLORENCE and TUCSON at EXIT 212.Turn right off the exit ramp onto AZ-79 SOUTH to FLORENCE and TUCSON. Take AZ-79 SOUTH to Florence.
Take U.S. 17 SOUTH to I-95 SOUTH.Take I-95 SOUTH to Savannah. To access the historic district, exit at EXIT 99A onto I-16 EAST, then take I-16 EAST to downtown.
Take HIGHWAY 99 SOUTH to the CANADA-U.S.A. BORDER.Cross at the border into BLAINE, WASHINGTON, U.S.A. Once you are past the border, continue straight on I-5 SOUTH.Take I-5 SOUTH through Washington and Oregon to I-10 EAST via the 210 EAST around Los Angeles (EXIT 161A off I-5 in CALIFORNIA). To bypass Seattle, take I-405 (EXIT 182 off I-5 in WASHINGTON). To bypass Portland, take I-205 (EXIT 7 off I-5 in WASHINGTON).Take I-10 EAST to U.S. 60 EAST to MESA - GLOBE at EXIT 154 in ARIZONA just past downtown Phoenix.take U.S. 60 (Superstition Fwy) EAST to AZ-79 SOUTH to FLORENCE and TUCSON at EXIT 212.Turn right off the exit ramp onto AZ-79 SOUTH to FLORENCE and TUCSON. Take AZ-79 SOUTH to Florence.
505 miles taking this route:Take I-79 NORTH from Charleston to I-90 EAST to BUFFALO at EXIT 178A near Erie, PENNSYLVANIA.Take I-90 EAST to I-490 to ROCHESTER at EXIT 47 off I-90 New York State THRUWAY (toll).Take I-490 to Rochester.
Florence, SC is Amtrak's Myrtle Beach stop. From there you can take the Palmetto north to Richmond or New York or south to Charleston or Savannah. You can also take the Silver Meteor north to Richmond or New York or south to Charleston, Savannah. or Florida.
Take I-66 WEST from Washington, D.C. to I-81 SOUTH to ROANOKE at EXIT 1A in VIRGINIA.Take I-81 SOUTH to I-64 WEST to LEXINGTON and CHARLESTON at EXIT 191.Continue WEST on I-64 to Louisville.
981 miles taking this route:Take I-26 WEST from Charleston to I-40 WEST to KNOXVILLE off EXIT 31B near ASHEVILLE, NORTH CAROLINA.Take I-40 WEST to I-24 WEST to CLARKSVILLE off EXIT 211 in downtown NASHVILLE, TENNESSEE. To bypass KNOXVILLE, take I-640 WEST (EXIT 393 off I-40 in TENNESSEE).Take I-24 WEST to U.S. 60 to WICKCLIFFE and PADUCAH off EXIT 4 in KENTUCKY. Turn LEFT off the exit ramp onto U.S. 60 WEST towards WICKLIFFE.Take U.S. 60 WEST to Springfield.