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Microsoft Office does not care about the file system at all. It can be run on any file system that compatible versions of Windows runs on (FAT32 and NTFS for XP, and just NTFS for Vista).

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Q: What file system runs Microsoft Office 2007?
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What does the x in docx mean?

A .docx file is a Microsoft Office Word document, but is only compatible with Microsoft Office Word 2007 and Microsoft Office Word 2010. A .doc file is compatible with previous versions of Microsoft Office Word.


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Microsoft offers a download for opening Office 2007 file formats in earlier versions of the Office Suite. Known as the Microsoft Office Compatibility Pack, this addon is available freely on the Microsoft Download Center.


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xlsx is the main extension used for Excel 2007.


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