What happened to Edward's sister?

Answer 1

Edward VI (1537 - 1553) son of Henry VIII (1491 - 1547) and his third wife, Jane Seymour (c1504-09 - 1537) had the following half sisters and brother:

Mary I (1516 - 1558) by Catherine of Aragon - first wife (1485 - 1536)

Elizabeth I (1533 - 1603) by Anne Boleyn - second wife(c1501-07 - 1536)

Catherine of Aragon did give birth to six children, but apart from Mary, they were stillborn or died within a few weeks. Anne Boleyn had at least two miscarriages.

Anne of Cleves (1515 - 1557)

Catherine Howard (c1520 - 1542)

Katherine Parr (c1512 - 1548)

did not bear Henry any children.

Henry also had an acknowledged illegitimate son:

Henry Fitzroy (1519 - 1536) Duke of Richmond (by Henry's mistress Elizabeth Blount)

There may have been other illegitimate children, possibly by Mary Boleyn, (and in particular her son, Henry Carey) another of Henry's mistresses and sister of Anne Boleyn; but they have not been confirmed or acknowledged probably due to the timing of King Henry's relationship with Mary Boleyn.

Answer 2

Edward's sister died from a terminal illness when they were children. Edward was devastated by her loss and it had a lasting impact on his life.