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What happens when ACTH levels are too low?

Updated: 11/16/2022
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GaleEncyofMedicine

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13y ago

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the hypothalamus produces corticotropin-releasing hormone (CRH) to stimulate the pituitary gland to make more ACTH. ACTH levels rise in response to stress, emotions, injury, infection, burns, surgery, and decreased blood pressure

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Q: What happens when ACTH levels are too low?
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How is ACTH production controlled?

ACTH production is primarily regulated by the hypothalamus and pituitary gland through a feedback mechanism. The hypothalamus releases corticotropin-releasing hormone (CRH) in response to stress or low cortisol levels, which then stimulates the pituitary gland to release ACTH. ACTH, in turn, stimulates the adrenal glands to produce cortisol. When cortisol levels are high, negative feedback mechanisms reduce the production of CRH and ACTH, thus maintaining hormonal balance.


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