Hexosaminidase is an enzyme that breaks down certain fats in the brain. This enzyme is either composed of an alpha and a beta subunit (HexA) or two beta subunits (HexB).
Lysosomes
Tay-Sachs disease
Tay-Sachs disease is abbreviated to TSD and is also known as GM2 gangliosidosis or Hexosaminidase A deficiency.
. One potential treatment focuses on the lack of the hexosaminidase A enzyme. If the enzyme can be replaced, then the GM2 deposits could be broken down into their component parts, and nerve cells could return to a state of proper function.
Charcot-Marie-Tooth disease is actually a heterogenous group of disorders known to be caused by variants on 40 genes. The most common form of CMT is caused by a duplication on chromosome 17 that results in an extra copy of the gene for Peripheral Myelin Protein 22 or PMP22. This duplication causes demyelination of the nerve axons, and, eventually, muscular atrophy. For more, visit www.charcot-marie-tooth.org.
Lysosomes
Tay-Sachs disease
Yongmin Hou has written: 'The analysis of the [alpha]-active site of human hexosaminidase A'
Tay–Sachs disease is also known as GM2 gangliosidosis or hexosaminidase A deficiency. Other names are: B variant GM2 gangliosidosis, GM2 gangliosidosis, type 1, Hexosaminidase alpha-subunit deficiency (variant B), Sphingolipidosis, Tay-Sachs and TSD.
Yes! Tay-Sachs is also known as GM2 gangliosidosis or Hexosaminidase A deficiency.
Tay-Sachs disease is abbreviated to TSD and is also known as GM2 gangliosidosis or Hexosaminidase A deficiency.
A mutation of the HEX A gene of chromosome 15 causes Tay-Sachs disease. As a result, the protein hexosaminidase A is not formed properly and GM2 ganglioside, the lipid normally broken down by hexosaminidase A, accumulates to toxic levels (especially in the brain).
Tay-Sachs disease (TSD) is a fatal condition caused by a deficiency of the enzyme hexosaminidase A (Hex-A).
Because Sandhoff disease and Tay-Sachs disease have similar clinical symptoms, distinguishing them requires biochemical analysis. This involves a test to measure enzyme activity of the two hexosaminidase enzymes.
Prevention involves identifying carriers of the disease and providing them with appropriate information concerning the chance of their offspring having Tay-Sachs disease. When the levels of hexosaminidase A are half the normal level.
chromosome 15 it causes the build up of a chemical called gangliosides because the defect causes the body to lack production of the protein hexosaminidase which breaks down the chemical.
Tay-Sachs is caused by a defective gene. Genes are located on chromosomes, and serve to direct specific development/processes within the body. The genetic defect in Tay-Sachs disease results in the lack of an enzyme called hexosaminidase A.