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What is the difference of g-protein receptor system and tyrosine kinase receptor?
Wiki User
∙ 7y ago
Receptor tyrosine kinases do not require the use of second messengers while G protein-coupled receptors need.
Wiki User
∙ 11y ago
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What Would be inhibited by a drug that specifically blocks the addition of phosphate groups to proteins?
receptor tyrosine kinase activity
BCR-ABL tyrosine kinase receptor?
Is the genetic abnormality which is a characteristic of a haematological malignancy, chronic myeloid leukemia.
What is Bruton's agammaglobulinemia tyrosine kinase?
It is an enzyme vital for the maturation of B cells
How do substances work by altering the ways cells function?
Like the receptors for other protein hormones, the receptor for insulin is embedded in the plasma membrane. The insulin receptor is composed of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha chains are entirely extracellular and house insulin binding domains, while the linked beta chains penetrate through the plasma membrane. The insulin receptor is a tyrosine kinase. In other words, it functions as an enzyme that transfers phosphate groups from ATP to tyrosine residues on intracellular target proteins. Binding of insulin to the alpha subunits causes the beta subunits to phosphorylate themselves (autophosphorylation), thus activating the catalytic activity of the receptor. The activated receptor then phosphorylates a number of intracellular proteins, which in turn alters their activity, thereby generating a biological response. Several intracellular proteins have been identified as phosphorylation substrates for the insulin receptor, the best-studied of which is insulin receptor substrate 1 or IRS-1. When IRS-1 is activated by phosphorylation, a lot of things happen. Among other things, IRS-1 serves as a type of docking center for recruitment and activation of other enzymes that ultimately mediate insulin's effects. from yo mama
What is the similarity of G-protein receptor system and Tyrosine-kinase receptor system?
both are plasma membrane receptors located at the cell surface's membrane. both are proteins that are hydrophilic and therefore cannot cross the lipid bilayer and requires second messengers to communicate with the nucleus of cells. activation of the receptors will activate other molecules in the activating cascades and the numbers of affected molecules will increase geometrically. however, activation of such receptors will cause desensitization/adaptation of the receptors themselves. the disability to desensitize can result to serious diseases such as cancer. Khairul Abu Bakar 2nd Year Medical Student National Univ.of Ireland, Galway
What membrane receptor undergoes dimerization and autophosphorylation?
tyrosine kinase receptor.
Growth factor hormones such as insulin bind to which type of receptor?
tyrosine kinase receptor!!
What Would be inhibited by a drug that specifically blocks the addition of phosphate groups to proteins?
receptor tyrosine kinase activity
BCR-ABL tyrosine kinase receptor?
Is the genetic abnormality which is a characteristic of a haematological malignancy, chronic myeloid leukemia.
What has the author Muriel Viegas written?
Muriel Viegas has written: 'The intrinsic tyrosine kinase activity of the epidermal growth factor receptor is necessary for phospholipase A2 activation'
What is Bruton's agammaglobulinemia tyrosine kinase?
It is an enzyme vital for the maturation of B cells
What is the function of receptor proteins?
Receptor proteins are designed so special molecules can bind to them, and send messages to the cell that trigger some sort of reaction within the cell.They are embedded in either the plasma membrane or cytoplasm of a cell, to which a mobile signaling (or "signal") molecule may attach.Sources: http://en.wikipedia.org/wiki/Receptor_proteins
What has the author Tomas Mustelin written?
Tomas Mustelin has written: 'Src family tyrosine kinases in leukocytes' -- subject(s): Genes, src, Genetics, Leucocytes, Leukocytes, Metabolism, Physiology, Protein-tyrosine kinase
In mammals g protein coupled receptors play a major role in mediating effects of various hormones not through?
activation of tyrosine kinase activity
What has the author Spencer Bruce Gibson written?
Spencer Bruce Gibson has written: 'Role of the TEC family tyrosine kinase EMT in T cell activation'
What causes sepa p disease?
CIPA is caused by a genetic mutation which prevents the formation of nerve cells which are responsible for transmitting signals of pain, heat, and cold to the brain. Overheating kills more than half of all children with CIPA before age 3. The genetic mutation is in the gene encoding the neurotrophic tyrosine kinase receptor (NTRK1 gene).
Which and how many genes are responsible for the thyroid cancer?
RET protooncogene mutation which encodes a transmembrane receptor with tyrosine kinase activity has been linked to PTC and activating mutation of BRAF Activating point mutations in the RAS oncogene has been found in patients with follicular adenoma and carcinoma and p53 mutation and PAX8-peroxisome proliferator-activated receptor gamma [PPAR γ1] and PIK3CA mutations and amplifications and PTEN mutations in the PI3K/Akt signaling pathway and beta-catenin mutations
