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An antiangiogenic is a drug which serves to inhibit angiogenesis.
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What is the role of antiangiogenic therapy in eye disease?
Excessive new blood vessels growing in the eye can cause vision loss and lead to blindness. Antiangiogenic treatments may prevent progressive loss of vision or even improve eyesight in patients.
How does antiangiogenic therapy work in arthritis?
Blood vessels that invade the joint release enzymes that destroy cartilage and other tissues in arthritis. Antiangiogenic drugs may relieve the arthritic pain and prevent bone joint destruction caused by these pathological and destructive blood vessels.
What is the purpose of antiangiogenic therapy?
Anti-angiogenic therapy is used to inhibit the formation of new blood vessels, which are necessary for the growth and spread of tumors. By blocking the blood supply to cancerous tumors, anti-angiogenic therapy can help slow down tumor growth and potentially shrink the tumor.
What is the etiology of Pregnancy induced hypertension?
In the first, the initiating cause results in the placenta producing factors (e.g., specific proteins, placental "debris") that enter the maternal circulation and are believed responsible for producing the next stage. This is the second stage, which results in the overt maternal "disease" (high blood pressure, kidney, liver and coagulation abnormalities). The overt disease depends not only on the action of the circulating factors from the placenta, but also the health of the mother, including diseases that may affect the vasculature (such as preexisting cardiovascular, renal, metabolic, and genetic factors; and obesity).A promising area of recent research involves the role of proteins produced by the placenta that inhibit angiogenesis (the production of new blood vessels). Two of these "antiangiogenic factors" (soluble Fms-like tyrosine kinase-1, and soluble endoglin) have been shown to produce a preeclampsia like disease in rodents. Their concentrations rise in the mother's circulation weeks to months before the disease manifests. Placentas of women destined to develop preeclampsia overproduce these proteins that then enter the mother's circulation. Neutralizing their actions is now being investigated in animal models, and in some studies has reversed the disease in rodents. . Excitement regarding these interventions is tempered by a limited understanding of the functional role of antiangiogenic substances in normal pregnancy.If the ability of these antiangiogenic proteins to cause preeclampsia is confirmed by research in humans, why the placenta overproduces them remains unknown. Hence, many of the other areas of investigation mentioned above may be important. Preeclampsia may have multiple causes, and other leads are being investigated, including prostaglandins, digoxin-like molecules, immunological mechanisms, autoantibodies that trigger receptors that lead to vessel constriction (agonistic autoantibodies to the angiotensin 1 receptor), oxidative stress, mitochondrial pathology, the impact of hypertension and prehypertension on endovascular health, and genes sensitive to low oxygen environments.
What is nasunin in eggplant?
Nasunin is high on the list of potent antioxidants. In this capacity it helps to neutralize free radicals, making it an excellent anti-aging phytonutrient. Nasunin has many additional health benefits. It has antiangiogenic properties which help it to fight cancer by restricting the growth of new blood vessels. It also helps keep blood vessels clear and relaxed. Biologically, nasunin functions by scavenging excess iron in the body and thereby preventing a free radical chain reaction that damages cells. In this way it is protective of brain cells and other parts of the nervous system. The most prominent natural source of nasunin is in the skin of eggplants. It was first isolated from the plant in 1933. This is what gives eggplant fruits the dark purplish-blue coloration. In eggplants it functions to protect the plant from environmental damage, especially from the sun. Currently, nasunin is not found in any commercially available supplements. However, because of its amazing properties nasunin supplementation will likely be available in the form of capsules in the near future.
Who is Anna O'Conner?
If you mean Anna O'Connor, She's the Founder of Anna's Hope(Charity fund research for a cure for those many precious children presently suffering from neuroblastoma) She was diagnosed with Stage IV, high risk Neuroblastoma at age 17, just prior to her senior year at Wheaton North High School. She has endured multiple rounds of chemotherapy, major surgery to remove the primary abdominal tumor, many rounds of radiation and has participated in numerous clinical trials including a high-dose radioactive isotope infusion (MIBG), monoclonal anti-bodies (3f8), a next generation targeted chemo (ABT-751), a newly engineered biological compound (CEP-701), another oral formulation, Fenretinide XLS, and rapamycin and sunitinib. Having progressed on Irinotecan & Temador, she's recently completed a trial using MIBG-Ultratrace and then was placed on an antiangiogenic called Thalidomide combined with a chemo, Temodar. Anna is enrolled in an adult clinical trial taking pf02341066, an ALK inhibitor and was on this breakthrough medicine for over a year. She is currently on a cytoxan/zometa/Avastin combination. Although still plagued by disease, spreading from several bones to her lungs, liver and multiple sites in her abdomen, she has graduated with her B.A. in Psychology from Wheaton College near her home in Wheaton, Illinois.
