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Clot resolution is also known as Fibrinolysis, it requires plasmin which is activated by the plasma protein plasminogen. The presence of a clot around the vessel activates the endothelial cells to release tissue plasminogen factor. Activated factor XII and Thrombin during clotting also serve as plasminogen activators. This causes most plamin to be confined to the clot, if plamin does move into the plasma it is quickly denatured by circulating enzymes as it would be harmful to other cells. Fibrinolysis begins within two days and continues over several days until the clot is dissolved.

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Q: What is blood clot resolution?
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