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What is linked recognition?

Updated: 4/28/2022
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Linked Recognition occurs when a B cell is activated by a helper T cell that responds to the same antigen as the B cell. The epitope recognized by the B cell must be "linked" to the epitope recognized by the helper T cell--in a manner such that both epitopes are physically linked in a certain manner. However, the two epitopes need not be the same.

The importance of linked recognition can be observed in maintaining self tolerance. Also, a B cell recognized by a helper T cell is up to 10,000 times more efficient at displaying peptide fragments on their MHC class II molecures than B cells that are not helped.

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