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To explain it in the simplest way i can think of, explained by a doctor in the Academy Award Winning movie Lorenzo's Oil, Myelin is like the rubber part on an electrical cord that gives it energy in some way (not sure how) and ALD or Adrenoleukodystrophy, affects it by eroding that part of it. I'm not sure though how this affects the bodies brain functions.
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∙ 13y ago
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How does the degereration of the myelin sheaths on cells in the white matter of the central nervous system result in the impaired brain functions in ALD patients?
Myelin sheaths in the central nervous system do the same basic job as they do in the peripheral nervous system. They insulate the axons, which are the conducting parts of nerve cells, so that they can carry their signal better. When this protective mechanism is damaged, as in ALD, the nerve cells cannot communicate properly and result in the signs and symptoms of ALD. Unfortunately this genetic disorder not usually caught in its early stages to provide effective treatment.
What is the most severe form of adrenoleukodystrophy?
The most severe form of ALD is called childhood ALD. About 35% of people with ALD have this type. These children usually have normal development in the first few years of life.
It insulates the axon of the neuron?
An insulating layer that surrounds the axon is a myelin sheath.
What is X-linked Adrenoleukodystrophy causes by?
X-linked ALD is caused by defects in the ABCD1 gene, also known as the ALDP (ALD protein) gene
What are schwann cell nucleus'?
myelin sheath peace.love.faith
How does the degereration of the myelin sheaths on cells in the white matter of the central nervous system result in the impaired brain functions in ALD patients?
Myelin sheaths in the central nervous system do the same basic job as they do in the peripheral nervous system. They insulate the axons, which are the conducting parts of nerve cells, so that they can carry their signal better. When this protective mechanism is damaged, as in ALD, the nerve cells cannot communicate properly and result in the signs and symptoms of ALD. Unfortunately this genetic disorder not usually caught in its early stages to provide effective treatment.
How does nicotine affect the myelin production?
Nicotine stimulates CREB phosphorylation which regulates the expression of myelin basic protein and myelin oligodendrocyte glycoprotein.
After several months of ALD what does Lorenzo's neuron look like?
It has lost its myelin sheath (clothes) so it can no longer be used to send messages from the brain to other parts of the body.
Why is a disease like ALD much more common in boys than in girls?
The most common type of ALD (adrenoleukodystrophy) is X-linked ALD. Than means that the gene for ALD is on the X chromosome. Because boys have only one X chromosome, if it has the ALD gene on it they will have the disease. Girls have two X chromosomes, so, in order to get ALD both of their X chromosomes would have to have an ALD gene. That would mean that both her father and her mother would have to have an ALD gene. Because males with ALD die before they can have children this would not happen. So girls don't get this type of ALD. There are other, more rare types of ALD that affect both boys and girls. So, all in all, fewer girls have ALD
Does a nervous breakdown affect the myelin sheaths?
No. It does not. It can not. It neither affect the neurons also.
What does demyelination affect?
The myelin sheath that surrounds the nerve
What is the prognosis for a person with adrenoleukodystrophy?
Prognosis for childhood and neonatal ALD patients is poor because of the progressive myelin degeneration. Death usually occurs between one and ten years after onset of symptoms.
Does simvastatin affect the myelin sheath?
yes, in many ways
What does ALD do to the white matter in the brain?
Myelin sheaths in the central nervous system do the same basic job as they do in the peripheral nervous system. They insulate the axons, which are the conducting parts of nerve cells, so that they can carry their signal better. When this protective mechanism is damaged, as in ALD, the nerve cells cannot communicate properly and result in the signs and symptoms of ALD. Unfortunately this genetic disorder not usually caught in its early stages to provide effective treatment.
How does the myelin sheath and synapse affect nerve impulses speed up or slow down?
Myelin sheath insulates axons for speedier signaling
What insulates nerve fibers?
Myelin sheaths insulate nerve fibers
What was the purpose of the ald symposium in lorenzo's oil?
To have scientists collaborate to help find a therapy for ALD
