Take I-65 SOUTH to Nashville bypassing Indianapolis via I-465 SOUTH.
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The shortest is I-80 East.
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In the shortest route the two largest would be Memphis and Nashville.
Through Houston, Texarkana, Memphis, Nashville and Louisville.
I-75 to Chattanooga, I-24 to Nashville, I-65 to Gary, IN, and I-90 into Chicago.
It is 354 mi, if you take I-40 E. This is the shortest route.
I-65 is the faster route. MapQuest states that the travel time from Chicago to Nashville is 7 hours 30 minutes via I-65 and 7 hours 57 minutes via I-57.
The results of your search for Nashville, TN (BNA) to Brussels (BRU)Shortest Flight Duration * 10 hours 55 mins * Via Chicago O'Hare International Apt, Chicago (ORD) * this includes transfer time at Chicago O'Hare International Apt, Chicago (ORD)
24W to 57N to 64W to 70W to 435N to 29N to 90W to 15N