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- Take I-64 or I-264 WEST to US-58 WEST.
- Take US-58 WEST to I-95 SOUTH to ROCKY MOUNT, NC in Emporia.
- Take I-95 SOUTH through Virginia, North Carolina, South Carolina and Georgia to I-4 WEST to ORLANDO at EXIT 260B in Florida.
- Take I-4 WEST to EXIT 101AB which is County Road 46A and FL-417 TOLL to INTERNATIONAL AIRPORT - SANFORD.
- Take EXIT 106B onto FL-417 TOLL to INTERNATIONAL AIRPORT - SANFORD.
- FL-417 TOLL bypasses downtown Orlando. Take FL-417 TOLL back to I-4 WEST in Orlando south.
- Continue on I-4 WEST to Tampa.
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