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Just take I-81 NORTH to Scranton.

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Q: What is the best route between Harrisburg Pennsylvania and Scranton Pennsylvania?
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What is the distance between Harrisburg Pennsylvania and Pittsburgh Pennsylvania?

Harrisburg, PA is approximately 243 miles from Pittsburgh, PA. If you travel by car, the best route to take is the PA Turnpike, which is a toll road. Plan to spend about 4 hours driving. In Pennsylvania we generally describe distances with time, for example: from Harrisburg, Pittsburgh is 4 hours away. If you travel by train, the Amtrak Pennsylvanian will take 5.5 hours and costs about $70.00 one way.


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