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940 miles (1,513 kilometres) in total taking this route:

  1. Take I-10 WEST from Houston to I-35 SOUTH to LAREDO via I-410 to bypass SAN ANTONIO. (EXIT 581 off I-10 to get onto I-410, SECOND RIGHT onto I-410 SOUTH ; EXIT 53 off I-410 to get onto I-35, SECOND RIGHT onto I-35 SOUTH to LAREDO.)
  2. Take I-35 SOUTH to SH-255 TOLL - COLUMBIA TOLL ROAD to MONTERREY off EXIT 24. Follow signs to SH-255 TOLL - COLUMBIA TOLL ROAD off the exit ramp.
  3. Take SH-255 TOLL - COLUMBIA TOLL ROAD to Mexico via the COLUMBIA-SOLIDARITY INTERNATIONAL BRIDGE (INTERNATIONAL BRIDGE NO. 3) (toll bridge). NOTE: this bridge is not in operation for 24 hours of the day. It is only open: 8:00 A.M.-12 MIDNIGHT, MONDAY-FRIDAY ; 8:00 A.M.-4:00 P.M., SATURDAY ; 12:00 NOON-4:00 P.M. SUNDAY. If you are driving at a time when the bridge is not in operation, continue on I-35 SOUTH to the END in the city of Laredo proper, where you will follow signs to INTERNATIONAL BRIDGE NO. 2 (JUÁREZ-Lincoln BRIDGE) (toll bridge).
  4. Cross either the COLUMBIA-SOLIDARITY INTERNATIONAL BRIDGE (INTERNATIONAL BRIDGE NO. 3) or the JUÁREZ-LINCOLN BRIDGE (INTERNATIONAL BRIDGE NO. 2) from LAREDO, Texas into NUEVO LAREDO, MEXICO.
  5. If you are coming from the COLUMBIA SOLIDARITY INTERNATIONAL BRIDGE (INTERNATIONAL BRIDGE NO. 3), turn left at the end of the bridge onto MEXICO 2, then continue following MEXICO 2 to MEXICO 85 towards MONTERREY. If you are coming from the JUÁREZ-LINCOLN BRIDGE (INTERNATIONAL BRIDGE NO. 2), continue straight past the bridge, then follow signs to MONTERREY. You will eventually go onto MEXICO 85.
  6. Take MEXICO 85 & 85D ('D' signifies a toll road) to MEXICO 40D towards SALTILLO, outside of MONTERREY. Bear right onto MEXIO 40D. It is critical that you take the toll roads in Mexico if they are available. They are of the highest standards and you would essentially be an idiot not to take them, except if you are critically short on cash, that is.
  7. Take MEXICO 40 to MEXICO 54D to SALTILLO.
  8. Take MEXICO 54D & 54 to MEXICO 57 towards MATEHUALA outside of Saltillo. EXIT LEFT.
  9. Take MEXICO 57 & 57D to Santiago de Querétaro.

It is 351 miles (565 km) from HOUSTON to the COLUMBIA BRIDGE and it is 948 kilometres (589 miles) from the COLUMBIA BRIDGE to SANTIAGO DE QUERÉTARO.

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