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To bind to antigens for B and T cells to identify as self or foreign.

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14y ago

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What does the medical abbreviation MHC mean?

MHC = major histocompatibility complex What makes up MHC are HLA's (human leukocyte antigens), which there are subclasses for.


When was MHC Krylya Sovetov created?

MHC Krylya Sovetov was created in 2008.


Does thymic selection destroy MHC molecules?

Thymic selection does not destroy major histocompatibility complex (MHC) molecules. Instead, it helps in the development of T cells by allowing them to recognize self-MHC molecules and self-antigens to ensure self-tolerance and proper immune function.


The function of an antigen-presenting cell depends on the presence of what?

The function of an antigen-presenting cell depends on the presence of major histocompatibility complex (MHC) molecules, which provide a platform for presenting antigens to T cells. Additionally, the presence of co-stimulatory molecules is crucial for activating T cells and initiating an immune response.


What is MHC?

Major Histocompatibility Complex


The MHC is important in a T cell's ability to?

The major histocompatibility complex (MHC) is important in a T cell's ability to recognize antigens presented by antigen-presenting cells. This recognition is crucial for initiating an immune response and coordinating the functions of different immune cells. Deficiencies in MHC expression or function can impact the ability of T cells to mount an effective immune response.


Why is it an Advantage to the population of species to have a highly polymorphic MHC region?

The advantage of having a highly polymorphic MHC is that it adds to variety of which it can bind to a peptide. If MHC cannot bind to a viral or bacterial peptide then your body cannot use its' adaptive immunity to fight off an infection. The T cell requires MHC to activate and if MHC is not binding to anything because it has such a small repertoire of alleles to create a MHC molecule, it will render T cells useless. So to have a highly polymorphic MHC gene that can encode to bind to many different peptides is advantageous for survival.


MHC antigens are?

Peptides


B-lymphocytes express both MHC-1 and MHC-2?

Yes they do. MHC 1 are expressed by all nucleated calls (except neurones) and platelets. MHC 11 are expressed by B-cells, macrophages and dendtitic cells. Therefore, some cells express both types.


Is MHC class 1 the same as HLA class 1?

The answer previously here about MHC referring to mice and HLA referring to humans is catagorically untrue! HLA and MHC are in fact the same, so HLA class 1 = MHC class 1. Same goes for class 2.


When MHC will be expressed?

MHC I and MHC II are always expressed. The antigen it presents on a cells surface can be foreign or it can be self. It is the T cell that determines whether what the MHC is displaying is self or not. Remember antigen can be protein, lipid, sugars, etc.


Where can one find information about the MHC?

MHC is an acronym for "major histocompatibility complex." If one desires to find out more about the MHC genetic issue, one might find reliable information on the government NIH website.