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MHC antigens are?
Peptides
Why does a patient's body is less likely to reject and allograft if it comes from a relative?
Because it is more likely that a relative will have the same MHCs (major histocompatibility complexes) on their cells. When immune cells patrol the body they will bind these complexes which tell them whether the cell they are binding is 'self" or "nonself". If they bind a MHC which they percieve as nonself, they may initate an immune response leading to rejection of the graft
What does the medical abbreviation MHC mean?
MHC = major histocompatibility complex What makes up MHC are HLA's (human leukocyte antigens), which there are subclasses for.
When was MHC Krylya Sovetov created?
MHC Krylya Sovetov was created in 2008.
Why is it an Advantage to the population of species to have a highly polymorphic MHC region?
The advantage of having a highly polymorphic MHC is that it adds to variety of which it can bind to a peptide. If MHC cannot bind to a viral or bacterial peptide then your body cannot use its' adaptive immunity to fight off an infection. The T cell requires MHC to activate and if MHC is not binding to anything because it has such a small repertoire of alleles to create a MHC molecule, it will render T cells useless. So to have a highly polymorphic MHC gene that can encode to bind to many different peptides is advantageous for survival.
MHC antigens are?
Peptides
B-lymphocytes express both MHC-1 and MHC-2?
Yes they do. MHC 1 are expressed by all nucleated calls (except neurones) and platelets. MHC 11 are expressed by B-cells, macrophages and dendtitic cells. Therefore, some cells express both types.
Is MHC class 1 the same as HLA class 1?
The answer previously here about MHC referring to mice and HLA referring to humans is catagorically untrue! HLA and MHC are in fact the same, so HLA class 1 = MHC class 1. Same goes for class 2.
When MHC will be expressed?
MHC I and MHC II are always expressed. The antigen it presents on a cells surface can be foreign or it can be self. It is the T cell that determines whether what the MHC is displaying is self or not. Remember antigen can be protein, lipid, sugars, etc.
Where can one find information about the MHC?
MHC is an acronym for "major histocompatibility complex." If one desires to find out more about the MHC genetic issue, one might find reliable information on the government NIH website.
Do T cells have major histocompatibility complex (MHC) molecules?
Yes, T cells have major histocompatibility complex (MHC) molecules.
Where are major histocompatibility complex-you MHC-you molecules located?
Each individual has a unique MHC profile Clinically important MHC are HLA(human leukocyte antigens) -A, -B -DR -expression of a particular combination of MHC genes Class I - are located on all nucleated cells Class II - are located on macrophages, dendritic cells, B cells.
Difference between MHC class1 and MHC class2 molecules?
MHC proteins express antigens on a cell surface for T cells to identify whether the antigens presented are self or foreign. There are two classes MHC I and MHC II. They differ in which cells they require to activate depending on the pathogen present.
Class II MHC molecules are found only on which of the following?
Presented by APCs as MHC-exogenous peptide complex
