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What is MHC?
Major Histocompatibility Complex
Whats the difference of precipitaion coagulation aggregation and flocculation?
Pricipitation reactions are due to a phase change that make use of soluble antigens. Agglutination reactions are the clumping of antigens particulate's and antibodies.Flocculation reactions are a fluffy form of precipitation reaction due to antigens and antibodies.
What is h and o antigens?
H antigens correspond to the antigenic type of the bacterial flagellaO antigens correspond to the antigenic type of the Lipopolysaccharide layer on the outer membrane of gram negative bacteriabacteria all have different antigenic types on their surface which react to different types of antibodies and are classified using this method. For example the pathogenic E. coli O157:H7 has the designation 157 for its O antigen meaning it will not react with antibodies with a different serotype.
What is the name of a surface membrane molecule that causes an immune reaction?
Antigens are surface membrane molecules that cause an immune reaction.
What are direct and indirect agglutination test?
Direct agglutination tests involve the clumping of particles, such as red blood cells or bacteria, directly by antibodies in a sample, indicating the presence of specific antigens. In contrast, indirect agglutination tests use coated particles, like latex beads, that bind to antibodies in the serum, resulting in visible clumping if the corresponding antigens are present. Both methods are widely used in clinical diagnostics to detect infections and autoimmune diseases.
What does the medical abbreviation MHC mean?
MHC = major histocompatibility complex What makes up MHC are HLA's (human leukocyte antigens), which there are subclasses for.
Which class of MHC proteins presents exogenous antigens?
Class ll
Does MHC interfere blood transfusioneven though the same blood group?
Yes, the MHC may interfere with transfusion even though the blood groups of the donor and the recipient are the same. Blood contains white and red blood cells. Blood grouping is for red blood cell antigens. White cells carry the MHC antigens. White blood cells are usually few in number in donated blood, so they are not a major concern. However, the patient may react to MHC antigens present in the transfused white blood. This is more common in patients who have received many transfusions before, since they are sensitized to white cell antigens (MHC).
Do T cells express MHC II?
No, T cells do not express MHC II. MHC II molecules are primarily found on antigen-presenting cells, such as dendritic cells, macrophages, and B cells, and are involved in presenting antigens to T cells for immune responses. T cells, on the other hand, express MHC I molecules, which present antigens to other immune cells.
What are antigens with only one antigenic site called?
Antigens with only one antigenic site are called Major histocompatibility complex (MHC)
When an antigen binds to a Class 1 MHC molecule it stimulates what cell?
Class I MHC molecules present antigens to cytotoxic T-cells (which are CD3+CD8+).
Difference between MHC class1 and MHC class2 molecules?
MHC proteins express antigens on a cell surface for T cells to identify whether the antigens presented are self or foreign. There are two classes MHC I and MHC II. They differ in which cells they require to activate depending on the pathogen present.
Class you MHC genes code for?
MHC genes code for the Major Histocompatibility Complex proteins. These proteins are essential for the immune system to distinguish self from non-self antigens and help in the presentation of antigens to T cells. The MHC genes are highly polymorphic, giving rise to diverse MHC proteins that enable recognition of a wide range of pathogens.
The MHC is important in?
MHC is important in adaptive immunity. It provides your adaptive immunity, T cells, processed antigens so that it can decide whether what your cell has is a foreign substance that needs to be destroyed or if it is self that needs to be left alone.
Where are major histocompatibility complex-you MHC-you molecules located?
Each individual has a unique MHC profile Clinically important MHC are HLA(human leukocyte antigens) -A, -B -DR -expression of a particular combination of MHC genes Class I - are located on all nucleated cells Class II - are located on macrophages, dendritic cells, B cells.
When MHC will be expressed?
MHC I and MHC II are always expressed. The antigen it presents on a cells surface can be foreign or it can be self. It is the T cell that determines whether what the MHC is displaying is self or not. Remember antigen can be protein, lipid, sugars, etc.
What self antigens is found on cell membranes?
Major histocompatibility complex (MHC) proteins, also known as human leukocyte antigens (HLAs), are self antigens found on cell membranes. These proteins play a key role in presenting foreign antigens to the immune system for recognition.
