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The plasma half-life is 8.5±3.2 hours; shorter and longer half-lives have been reported for children and elderly subjects, respectively.
Peak plasma concentrations of diphenhydramine are reached in 2-3 hours.
from: National Highway and Traffic Safety Administration (http://www.nhtsa.dot.gov/people/injury/research/job185drugs/diphenhydramine.htm) accessed Nov. 17, 2008
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