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What is the MHC, and what is its role in immunity?

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Georgianna Rohan

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Q: What is the MHC, and what is its role in immunity?
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The MHC is important in?

MHC is important in adaptive immunity. It provides your adaptive immunity, T cells, processed antigens so that it can decide whether what your cell has is a foreign substance that needs to be destroyed or if it is self that needs to be left alone.


What is the role of MHC?

MHC is to present on a cell's surface for your T cells and antibodies to determine if it is self or foreign.


What do IgE antibodies T cell receptors and MHC molecules have in common?

They are all players of your adaptive immunity.


Is humoral immunity mhc class II?

No, it's cellulair. Handy to be recognized by the cytotoxic T-cells.


Why is it an Advantage to the population of species to have a highly polymorphic MHC region?

The advantage of having a highly polymorphic MHC is that it adds to variety of which it can bind to a peptide. If MHC cannot bind to a viral or bacterial peptide then your body cannot use its' adaptive immunity to fight off an infection. The T cell requires MHC to activate and if MHC is not binding to anything because it has such a small repertoire of alleles to create a MHC molecule, it will render T cells useless. So to have a highly polymorphic MHC gene that can encode to bind to many different peptides is advantageous for survival.


What is the role of cytotoxic T cells and describe their mechanism of action?

The role of cytotoxic T cells is to alert Class I MHC molecules to a foreign antigen. This is achieved by the foreign antigen associating with the MHC molecule and being moved out to the cell surface, where the cytotoxic T cell alerts the MHC molecule of the infection.


Does mhc recognize bacteria?

MHC doesn't "recognize" bacteria or anything. It's job is simply take up the broken peptides. These peptides can be originally from a virus, bacteria, or from the cell itself (self). It will take these antigen that it can bind to and bring it to the cells surface. Your adaptive immunity cells (B and T cells) job is to "see" what the MHC has to offer and identify it as self (leave alone) or as foreign (need to destroy).


What are the two components of specific immunity?

Humoral Immunity- acquired immunity in which the role of circulating antibodies is predominant. Natural Immunity- the resistance of the normal animal to infection


How does involvement of MHC 1 and MHC 2 help immune system?

MHC IMHC I is present in all cells except red blood cells (they lack nuclei). MHC I will present an intravesicular antigen to the cells surface for it to be identified as self or foreign by your adaptive immunity cells.MHC IIMHC II is present in professional antigen presenting cells which include: macrophages, B cells and dendritic cells. These cells will engulf bacteria, soluble proteins, viruses, etc. Whatever was taken into the cell becomes processed in the increasingly acidic endosome that eventually will cut the antigen into peptides. MHC II transported from the ER will meet up with this endosome and the peptides will bind to MHC II for it to eventually present on the cells surface.


What role do memory cells play in immunity?

no


What does the medical abbreviation MHC mean?

MHC = major histocompatibility complex What makes up MHC are HLA's (human leukocyte antigens), which there are subclasses for.


When was MHC Krylya Sovetov created?

MHC Krylya Sovetov was created in 2008.