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Mifepristone and misoprostol use is a two-step method.

  • First, your doctor gives you a dose of mifepristone tablets by mouth. Mifepristone causes the placenta to separate from the endometrium. It also softens the cervix and increases uterine contractions to allow the uterine contents to pass. For reference, see a picture of the reproductive organs .
  • Second, you take tablets of misoprostol by mouth or insert them vaginally, usually within 48 hours of mifepristone. Depending on the dose and how it is given, this could be as soon as 6 hours after the mifepristone.1 Some doctors may give misoprostol buccally (dissolved between the gums and cheek). Misoprostol causes uterine contractions so that your body passes the uterine contents. Some clinics may have you stay for 4 hours after misoprostol is given, because if serious side effects occur, they usually occur in this time period and can then be treated. The pregnancy may end in the clinic or later at home. Some doctors allow their patients to take misoprostol at home and then the pregnancy ends (like a miscarriage) at home.

A medical abortion usually requires at least two visits to your doctor over several weeks. For the first visit, one medicine is taken during the visit and a second medicine is given to be taken at home. The second visit is a follow-up appointment, usually scheduled about 2 weeks after the first visit, to make sure the pregnancy has ended and no complications are present. If a medical abortion is not successful, a surgical abortion is then done to complete the process because misoprostol can cause fetal abnormalities.

You can take pain medicine by mouth for this medical procedure.

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