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Presynaptic neurons release the neurotransmitter in response to an action potential. Postsynaptic neurons receive the neurotransmitter (and can however become presynaptic to the next nerve cell, if the neurotransmitter has stimulated the cell enough).
Presynaptic neuron sends postsynaptic receives
Neurotransmitters are released in response to stimulation. They alter the physiology of the postsynaptic cell. They are synthesized by a presynaptic neuron. They bind to specific receptors on the postsynaptic cell.
Let's picture a presynaptic neuron, a synaptic cleft, and a postsynaptic neuron. An action potential reaches the terminal of a presynaptic neurone and triggers an opening of Ca ions enters into the depolarized terminal. This influx of Ca ions causes the presynaptic vesicles to fuse with the presynaptic membrane. This releases the neurotransmitters into the synaptic cleft. The neurotransmitters diffuse through the synaptic cleft and bind to specific postsynaptic membrane receptors. This binding changes the receptors into a ion channel that allows cations like Na to enter into the postsynaptic neuron. As Na enters the postsynaptic membrane, it begins to depolarize and an action potential is generated.
Divergent
spatial summation
neuromuscular junctions
chemical synapse
An EPSP is an excitatory postsynaptic potential, which represent input coming from excitatory cells, whereas an inhibitory postsynaptic potential represents input driven by inhibitory presynaptic cells.
endocannabinoids
Diverging Circuit
Receptors for the various neurotransmitters are located on both the presynaptic and postsynaptic nerve terminals of the neuron.