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acetaminophen (n-acetate of 4-aminophenol)

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The product formed is acetaminophen. This reaction involves acetylating the amino group of p-aminophenol using acetic anhydride in the presence of sodium hydroxide to form acetaminophen.

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Q: What is the product formed by the acetylation of p-aminophenol with acetic anhydride and NaOH?
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Why add of little amount from acetic anhydride in synthesis of acetanilide?

Adding a small amount of acetic anhydride helps to facilitate the acetylation reaction with aniline, leading to the formation of acetanilide. The acetic anhydride serves as an acetylating agent that transfers an acetyl group to the amine group of aniline, resulting in the desired product. The use of an excess of acetic anhydride is avoided to prevent side reactions and to optimize the yield of acetanilide.


Why Acetic acid not used in acetylation?

Acetic acid is not used in acetylation reactions because it is a weak acid and does not provide enough acidity for the reaction to occur effectively. Stronger acids, such as acetic anhydride or acid chlorides, are commonly used in acetylation reactions to ensure efficient acetylation of the desired molecule.


What effect would the addition of a strong acid HCl have on the reaction of p-aminophenol and acetic anhydride?

The strong acid HCl would protonate the amine group in p-aminophenol, making it more reactive towards acetic anhydride. This would increase the rate of acetylation of p-aminophenol, leading to faster formation of the product, acetaminophen.


Reaction of methyl amine and acetic anhydride?

The reaction between methylamine and acetic anhydride results in the formation of N-methylacetamide as the primary product. In this reaction, acetic anhydride reacts with methylamine to form an amide functional group. This reaction is a common method for the synthesis of amides in organic chemistry.


What would happen if the excess acetic anhydride is not removed in the reaction vessel?

If excess acetic anhydride is not removed from the reaction vessel, it can lead to side reactions or undesired byproducts in the final product. It could also affect the purity of the desired compound and make purification more challenging. Additionally, it can pose safety hazards as acetic anhydride is a corrosive and hazardous chemical.

Related questions

Why add of little amount from acetic anhydride in synthesis of acetanilide?

Adding a small amount of acetic anhydride helps to facilitate the acetylation reaction with aniline, leading to the formation of acetanilide. The acetic anhydride serves as an acetylating agent that transfers an acetyl group to the amine group of aniline, resulting in the desired product. The use of an excess of acetic anhydride is avoided to prevent side reactions and to optimize the yield of acetanilide.


Why Acetic acid not used in acetylation?

Acetic acid is not used in acetylation reactions because it is a weak acid and does not provide enough acidity for the reaction to occur effectively. Stronger acids, such as acetic anhydride or acid chlorides, are commonly used in acetylation reactions to ensure efficient acetylation of the desired molecule.


What effect would the addition of a strong acid HCl have on the reaction of p-aminophenol and acetic anhydride?

The strong acid HCl would protonate the amine group in p-aminophenol, making it more reactive towards acetic anhydride. This would increase the rate of acetylation of p-aminophenol, leading to faster formation of the product, acetaminophen.


How do you make paracetamol?

Add 4-aminophenol to acetic anhydride. The product is paracetamol.


Reaction of methyl amine and acetic anhydride?

The reaction between methylamine and acetic anhydride results in the formation of N-methylacetamide as the primary product. In this reaction, acetic anhydride reacts with methylamine to form an amide functional group. This reaction is a common method for the synthesis of amides in organic chemistry.


What would happen if the excess acetic anhydride is not removed in the reaction vessel?

If excess acetic anhydride is not removed from the reaction vessel, it can lead to side reactions or undesired byproducts in the final product. It could also affect the purity of the desired compound and make purification more challenging. Additionally, it can pose safety hazards as acetic anhydride is a corrosive and hazardous chemical.


How do you make triacetate?

Triacetate is a synthetic cellulose-based material made by acetylating cellulose with acetic anhydride to create a cellulose triacetate. This process involves combining cellulose with acetic anhydride under controlled conditions to achieve the desired degree of acetylation, typically resulting in a highly durable and wrinkle-resistant material used in textiles and film.


Reaction of aniline with glacial acetic acid?

Aniline reacts with glacial acetic acid to form N-acetylaniline as the primary product. This reaction involves the acetylation of the amino group of aniline by the acetic acid to form the acetylated product. The reaction is usually carried out in the presence of a catalyst like sulfuric acid to facilitate the acetylation process.


What is the reaction when zinc acetic anhydride and glacial acetic acid are combine?

When zinc is reacted with acetic anhydride and glacial acetic acid, a complex called zinc acetate is formed. The reaction typically involves the displacement of acetic anhydride by acetic acid to form zinc acetate. The overall reaction is a redox reaction where zinc is oxidized and acetic anhydride is reduced.


Is acetic anhydride an acid or a base?

An anhydride is not an acid and not a base.


What is the balanced equation for the reaction between salicylic acid and acetic anhydride?

The balanced equation for the reaction between salicylic acid and acetic anhydride to form aspirin (acetylsalicylic acid) is: salicylic acid + acetic anhydride → aspirin + acetic acid.


What are the compound names for salicylic acid and acetic anhydride?

The compound name for salicylic acid is 2-hydroxybenzoic acid, and for acetic anhydride it is ethanoic anhydride.