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Hemoglobin is a protein, which is composed of linked amino acids.
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∙ 13y ago
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What is the difference between normal and sickle cell hemoglobin?
loss of only one amino acid from the normal hemoglobin molecule
What diseases arises from an amino acid change in protein hemoglobin?
sickle cell disease
In which hereditary disease does abnormal hemoglobin differ from normal hemoglobin by only a single amino acid?
Sickle-cell anemia
In sickle cell what amino acid is changed?
Glutamate is substituted for a valine at position 6. But this is not an amino acid problem, it's the construction of hemoglobin that's in error.
What is the difference between normal and sickle-cell hemoglobin based on?
terminal amino acid of the beta chain
How does sickle cell hemoglobin differ from normal hemoglobin?
Sickle cell hemoglobin differs from normal hemoglobin primarily due to a single amino acid substitution in the hemoglobin protein chain. In sickle cell disease, a person inherits two copies of an abnormal hemoglobin gene, usually referred to as HbS. In normal hemoglobin (HbA), the amino acid glutamic acid is present at a specific position in the beta chain of the hemoglobin protein. However, in sickle cell hemoglobin (HbS), this glutamic acid is replaced by valine due to a genetic mutation. This change causes the hemoglobin molecules to stick together under certain conditions, forming long, rigid structures that distort red blood cells into a sickle or crescent shape.
What causes sickle cell allele?
A mutation in one amino acid of one of the subunits making up hemoglobin.
What common genetic variation which causes a change in the amino acid sequence in the structure of hemoglobin leads to what disease?
Sickle cell
Compare the normal allele for hemoglobin with the sickle cell allele How does this difference affect the persons red blood cells?
The amino acid sequence of the sickle cell allele for hemoglobin varies from the normal allele for hemoglobin by one amino acid. The sickle cell allele for hemoglobin has valine instead of glutamic acid. When the oxygen level of the blood decreases, the hemoglobin molecules come out of solution, stick together, and form long chains that cause the red blood cells to become sickle shaped.
What disease arises from an amino acid change in the protein hemoglobin?
Sickle Cell disease A disease that involves misshaped cells that can easily cause blood clots.
Sickle-cell anemia is a condition that results from achange of one amino acid in the protein hemoglobin why is this condition a genetic disorder?
prickle prums
An example of mutation?
The substitution of one triplet code in the DNA that codes for an mRNA that codes for an amino acid that makes up a protein. Sickle cell trait is an example of this. One amino acid substitution in a B chain of hemoglobin and you have an allele that will code for sickle cell trait.
