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How does sickle cell hemoglobin differ from normal hemoglobin?
Wiki User
∙ 11y ago
Sickle cell hemoglobin differs from normal hemoglobin primarily due to a single amino acid substitution in the hemoglobin protein chain. In sickle cell disease, a person inherits two copies of an abnormal hemoglobin gene, usually referred to as HbS.
In normal hemoglobin (HbA), the amino acid glutamic acid is present at a specific position in the beta chain of the hemoglobin protein. However, in sickle cell hemoglobin (HbS), this glutamic acid is replaced by valine due to a genetic mutation. This change causes the hemoglobin molecules to stick together under certain conditions, forming long, rigid structures that distort red blood cells into a sickle or crescent shape.
Saadia Khalid
Wiki User
∙ 11y agoThe difference is in the quaternary structure.
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Is the mutation for hemoglobin S harmful or beneficial?
Hemoglobin S. This the predominant hemoglobin in people with sickle cell disease. The alpha chain is normal. The disease-producing mutation exists in the beta chain, giving the molecule the structure, a2bS2. People who have one sickle mutant gene and one normal beta gene have sickle cell trait which is benign.
What is the name of the condition of one sickle cell gene and one normal hemoglobin gene?
malaria
What condition is a person with only ONE sickle cell gene and one normal hemoglobin gene more capable of surviving than someone who has no sickle cell genes?
malaria
Compare the normal allele for hemoglobin with the sickle cell allele How does this difference affect the persons red blood cells?
The amino acid sequence of the sickle cell allele for hemoglobin varies from the normal allele for hemoglobin by one amino acid. The sickle cell allele for hemoglobin has valine instead of glutamic acid. When the oxygen level of the blood decreases, the hemoglobin molecules come out of solution, stick together, and form long chains that cause the red blood cells to become sickle shaped.
What is the causative agent of sickle cell?
Sickle cell disease is caused when someone inherits sickle shaped hemoglobin. It is a disease that can be managed, but not cured.
In which hereditary disease does abnormal hemoglobin differ from normal hemoglobin by only a single amino acid?
Sickle-cell anemia
What are the pros for SICKLE CELL ANEMIA?
The pro of sickle cell hemoglobin is that if you have only one allele for sickle cell hemoglobin and the other allele is normal, then you are immune to malaria.
What protein is not normal in people with sickle-cell disease?
It is Hemoglobin
What protein is not normal in people with sickle- cell disease?
Hemoglobin
What is the normal Hemoglobin level in Sickle Cell disease?
8
How is sickle cell hemoglobin differs from normal hemoglobin?
Matt Jones has herpes in the butt hole!
Why does sickle cell hemoglobin migrate slower than normal hemoglobin during electrophoresis?
because of the change of AA- in normal cell- from Glutamic acid (negativity charged) to Valine (uncharged) -in sickle cell- the charge will be missing in the sickle cell that why the electrophoresis will become slower because of the missing charge
How does disease affect the cell?
Sickle cell disease is a mutation in the gene that codes for hemoglobin, which causes the hemoglobin and the cell to become elongated and look like a sickle rather than its normal disc shape.
Why does sickle cell hemoglobin migrate slower than normal hemoglobin during gel electrophoresis?
because of the change of AA- in normal cell- from Glutamic acid (negativity charged) to Valine (uncharged) -in sickle cell- the charge will be missing in the sickle cell that why the electrophoresis will become slower because of the missing charge
What is the difference between normal and sickle cell hemoglobin?
loss of only one amino acid from the normal hemoglobin molecule
What is the name of the condition of one sickle cell gene and one normal hemoglobin gene?
malaria
Is the mutation for hemoglobin S harmful or beneficial?
Hemoglobin S. This the predominant hemoglobin in people with sickle cell disease. The alpha chain is normal. The disease-producing mutation exists in the beta chain, giving the molecule the structure, a2bS2. People who have one sickle mutant gene and one normal beta gene have sickle cell trait which is benign.
