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What is the significance of plasma drug concentration measurement?
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∙ 10y ago
klir
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∙ 10y ago
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What is Significance of plasma drug concentration measurement?
klir
Clinical significance of determination plasma half life of drug?
Plasma half life is the most important factor determining the dosage frequency. it also decides the time taken for the drug to reach steady state plasma concentration, which takes about 4-5 half lives to achieve. we can calculate how long the drug is going to stay in the body by knowing its half life as it is the time taken for the drug concentration to halve.
Why use plasma concentration rather than blood concentration in monitoring drug concentration in the body?
Most compounds are given as their concentration in blood plasma as well as with the conditions of collection. It is a form of standardization used in order to compare results across laboratories and over time. As blood volume and percent hematocrit (a measure of red blood cells) are fairly constant relative to body mass using the concentration in plasma ensures consistency in measurement. Another factor is that red blood cells are not equilibrated with the concentration of all compounds outside the cell equally. Transportation of compounds across the cell membrane is regulated.
Why do children need smaller doses if medicines than adults need?
in pharmacokinetics, we can use volume distribution (Vd) of a drug to calculate the dose that needs to be prescribed. volume distribution is the theoretical volume the drug will have to occupy (if it were uniformly distributed), to provide a concentration as it currently is in blood plasma. Vd = (amount of drug in blood) / (drug plasma concentration) children are physically smaller than adults, hence they will have a smaller volume distribution and hence only need to be prescribed a smaller dosage of the drug. h
When donating plasma do you have to pass a drug test?
No
What is meant by 'plasma concentration of drug'?
The Plasma Concentration is how much of a drug is in your blood. If injected IV, it will spike quickly. Otherwise there will be an absorption curve depending on the administration method. It will also have an exponential decay curve that generally follows half lives. The decay curves can, of course, be altered by things like kidney and liver function (where most drugs are either excreted or metabolized). The other to note is that some drugs are fat soluble and others are water soluble. Water soluble drugs are frequently excreted quickly through the kidneys. Fat soluble drugs can get stuck in your FAT and can stay in the body for an extended period. One additional thing about plasma concentration. The goal may be to keep the plasma concentration between a low "active" level and a high "toxic" level, with, of course, certain safeguards in place. Not all of the drug will be excreted before the second dose... and drugs can build up in the body over time. Sometimes a "loading dose" is good, for example starting with 3 aspirin for the first dose and 2 after that.
Does csl plasma centers drug screen?
Yes.
What is the difference between LSD and plasma TV's?
LSD is illusional drug.. plasma TV is a digital television
Which drug is binding with plasma protein?
Many drugs bind with your plasma proteins or albumins. An example is Warfarin (Coumadin) which is 90% bound to plasma proteins.
What is the measurement for iu?
IU is not a measurement of mass or weight like others but ti is the measurement of potency of a drug such as...vitamin capsules. =)
What is time transition?
the time for the drug to reach the intestine,important for drug efficiency measurement
Why is athletes have drug before the race?
to keep concentration
