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Why do children need smaller doses if medicines than adults need?
Wiki User
∙ 11y ago
in pharmacokinetics, we can use volume distribution (Vd) of a drug to calculate the dose that needs to be prescribed.
volume distribution is the theoretical volume the drug will have to occupy (if it were uniformly distributed), to provide a concentration as it currently is in blood plasma.
Vd = (amount of drug in blood) / (drug plasma concentration)
children are physically smaller than adults, hence they will have a smaller volume distribution and hence only need to be prescribed a smaller dosage of the drug.
h
Wiki User
∙ 11y ago
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