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This is a difficult question to answer because it is subjective. What one person feels is the worst may not be what someone else does. Also the subject matter is kind of macabre.

One of the worst types of birth defects that I can think of off hand is anencephaly. Anencephaly is, like spina bifida, is a defect in the formation of the neural tube, but in this case the fetus does not develop a brain. They may still retain a brain stem so reflex actions like breathing can still happen, but the part of the brain that allows for consciousness is not there. Invariably these babies do not survive long after birth.

In most cases severe malformation results in spontaneous abortion.

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Q: What is the worst birth defect on record?
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