Varicose* veins are twisted, enlarged veins near the surface of the skin. They are most common in the legs and ankles. They usually aren't serious, but they can sometimes lead to other problems.
Varicosities are Knoblike swellings of certain autonomic axons containing mitochondria and synaptic vesicles.
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Varicosities veins can be recognized if one looks out for abnormal veins in the shape of dots, popping on ones skin. The shape and color of varicisities are also different.
Irregularly swollen or enlarged; affected with, or containing, varices, or varicosities; of or pertaining to varices, or varicosities; as, a varicose nerve fiber; a varicose vein; varicose ulcers., Intended for the treatment of varicose veins; -- said of elastic stockings, bandages. and the like.
Voltage-gated Sodium ions and Potassium ions channels
Edema of the surrounding tissue, ankles, and calves, is not usually a complication of primary (superficial) varicose veins and, when seen, usually indicates that the deep veins may have varicosities or clots.
Acute inflammation (e.g. osteitis, periostitis) Acute circulatory disturbance Acute dermatological problem Local infection Local malignancy New burns Potential thrombus/emboli, varicosities Abdominal tumor, aneurysm, pregnancy, menstruation
The parasympathetic division of the autonomic innervation of the heart releases acetylcholine from its varicosities (the sites where neurotransmitter is released). The acetylcholine binds to M-2 muscarinc receptors to mediate the negative chronotropic (slowing of heart rate) effect. This also mediates a negative inotropic (lowering of force of contraction) effect.
Varicose veins most often occur in people who must sit or stand a lot. More women than men get varicose veins, and more women during or after child-bearing ages develop varicosities. They mostly occur in the lower legs, from the knee down to the ankle, but mostly around the knee and upper calf.
Varicose veins are caused by a defect in the valves directing one way flow inside the veins. When the valves are not functioning correctly, the blood backs up into the surface (superficial) veins and presents as varicosities. The reason that it is more likely to occur in the legs is that there is a greater fluid pressure caused by gravity's effect on the column of blood within your body.
Varicose veins can develop in the deep veins also. Varicose veins in the superficial veins are called primary varicosities, while varicose veins in the deep veins are called secondary varicosities.
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