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No fuel is getting to the cylinder, if there is good spark, assuming you checked the plug, wire and distrubitor. If spark is good right at the plug, then the intake valve is stuck shut.

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Q: What is wrong with your 350 new Holley Carburetor GM distributor good compression 155 to 175 good spark but cylinders 1 2 and 6 do not work?
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What is wrong with your 350 engine compression is good 155 to 175 new Holley carburetor GM distributor good spark all over but cylinders 1 2 and 6 not working?

You need to go back to the basics: Are the plug wires connected properly? If they're out of sequence (at the distributor) you'll definitely see what you're describing. Have you checked the individual plugs? Are they fouled? Wet? Is there a vacuum leak that's making the affected cylinders a bit too lean? Beyond that, it's just a matter of isolating the problem and attacking it one step at a time. Good luck.


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