Globular proteins.
No, large polar molecules cannot pass through the plasma membrane.
The three molecules that cannot easily pass through the membrane are large molecules, charged molecules, and polar molecules.
Large molecules such as proteins and nucleic acids cannot pass through the cell membrane.
Recently had a homework on the cell membrane, i do know that larger molecules that cant fit through the polar heads into the cell (like gases can...and small molecules?!) can get through only if they qualify the shape fitting of the channel protein- the one that reaches all the way from the outside to the inside of the membrane. hope this helps
Large polar molecules pass through the membrane by using specific transport proteins that facilitate their movement across the lipid bilayer.
Globular proteins
Large molecules can enter a cell through endocytosis, where the cell membrane folds around the molecule, forms a vesicle, and brings it into the cell. This process allows the cell to take in nutrients, signaling molecules, and other substances that are too large to pass through the membrane directly.
Large polar molecules enter the cell through facilitated diffusion or active transport, which require the assistance of specific protein channels or carriers in the cell membrane. These proteins help transport the molecules across the membrane against a concentration gradient or when the molecules are too large to pass through on their own.
Sugar molecules do not diffuse through a plant cell membrane because they are too large and polar to pass through the hydrophobic interior of the lipid bilayer. Instead, sugar molecules are transported across the membrane by specific transport proteins, such as sugar transporters, that facilitate their movement into the cell.
Large molecules such as proteins are typically unable to move across the membrane during osmosis. One example is starch molecules, which are too large to pass through the membrane pores.
vacuoles
Globular proteins.