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Opium derivatives come from Opium Poppies. Synthetic opiates are made in the laboratory. Cocaine is derived from Coca leaves, which are also considered narcotics by the DEA.

Note: The word "narcotic" means "sleep-inducing." It is technically improper to refer to cocaine as a narcotic, because it is a stimulant. This is indicative of the ignorance of the folks who crafted the drug laws in the US.

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Q: What plant is used for narcotics?
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