If the S-10 was equiped with a 4.3 liter engine the transmission will probably fit the 350. The transmission used with the 2.8 liter engine WILL NOT fit the 350 engine.
NO.
NO it will not.
Yes
Yes
Yes
Will a Chevy blazer engine fit in a Chevy s10 pickup
No.
Will a Chevy Blazer engine fit in a Chevy s10 pickup
No, different bolt pattern.
No.
A direct bolt in, no.
no